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ELISA Kit for Mouse Serine/threonine-protein kinase PAK 1

SKU : BHE13808252

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13344m
Alternative Names	Alpha-PAK ; CDC42/RAC effector kinase PAK-A ; p21-activated kinase 1 ; PAK-1 ; p65-PAK ; Paka
Categories	Elisa
Function	The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
Specificity	Natural and recombinant Mouse Serine/threonine-protein kinase PAK 1
Detection Range	0.156-10ng/ml
Entryname	PAK1_MOUSE
Method Type	Sandwich
Platform	PF00786
Protein Name	Serine/threonine-protein kinase PAK 1
Sensitivity	0.08ng/mL
Sequence	50: MSNNGVDIQD ; KPPAPPMRNT ; STMIGAGSKD ; TGTLNHGSKP ; LPPNPEEKKK ; 100: KDRFYRSILP ; GDKTNKKREK ; ERPEISLPSD ; FEHTIHVGFD ; AVTGEFTGMP ; 150: EQWARLLQTS ; NITKSEQKKN ; PQAVLDVLEF ; YNSKKTSNSK ; KYMSFTDKSA ; 200: EDYNSSNTLN ; VKTVSETPAV ; PPVSEDDEDD ; DDDATPPPVI ; APRPEHTKSV ; 250: YTRSVIEPLP ; VTPTRDVATS ; PISPTENNTT ; PPDALTRNTE ; KQKKKPKMSD ; 300: EEILEKLRSI ; VSVGDPKKKY ; TPFEKIGQGA ; SGTVYTAMDV ; ATGQEVAIKQ ; 350: MNLQQQPKKE ; LIINEILVMR ; ENKNPNIVNY ; LDSYLVGDEL ; WVVMEYLAGG ; 400: SLTDVVTETC ; MDEGQIAAVC ; RECLQALEFL ; HSNQVIHRDI ; KSDNILLGMD ; 450: GSVKLTDFGF ; CAQITPEQSK ; RSTMVGTPYW ; MAPEVVTRKA ; YGPKVDIWSL ; 500: GIMAIEMIEG ; EPPYLNENPL ; RALYLIATNG ; TPELQNPEKL ; SAIFRDFLQC ; 545: CLEMDVEKRG ; SAKELLQHQF ; LKIAKPLSSL ; TPLMHAAKEA ; TKNNH
Sequence Length	545
String	O88643
Sub Unit	Homodimer in its autoinhibited state. Active as monomer. Interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. Binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. Component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. Interacts with ARHGEF7. Also interacts with CRIPAK. Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM (via cytoplasmic domain); the interaction is direct and enhanced in presence of RAC1 (By similarity). Interacts with DSCAM and NISCH. Interacts with SCRIB.

Uniprot	O88643
Gene Name	Pak1
Immunogen Species	Mus musculus (Mouse)
Unigene	Mm.260227

Reference	1. "Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes." Burbelo P.D., Kozak C.A., Finegold A.A., Hall A., Pirone D.M. Gene232:209-215(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. Lubec G., Sunyer B., Chen W.-Q. Submitted (2009-01) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 204-215; 276-299; 309-320; 372-388 AND 472-489;IDENTIFICATION BY MASS SPECTROMETRY strain: OF1. tissue: Hippocampus. 3. "p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis." Schurmann A., Mooney A.F., Sanders L.C., Sells M.A., Wang H.G., Reed J.C., Bokoch G.M. Mol. Cell. Biol.20:453-461(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 4. "Pak1 phosphorylation on T212 affects microtubules in cells undergoing mitosis." Banerjee M., Worth D., Prowse D.M., Nikolic M. Curr. Biol.12:1233-1239(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-212 5. "Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1." Luo Z.G., Wang Q., Zhou J.Z., Wang J., Luo Z., Liu M., He X., Wynshaw-Boris A., Xiong W.C., Lu B., Mei L. Neuron35:489-505(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NEUROMUSCULAR JUNCTION DEVELOPMENT;INTERACTION WITH DVL1 AND MUSK 6. "The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK." Alahari S.K., Reddig P.J., Juliano R.L. EMBO J.23:2777-2788(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NISCH 7. "The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak." Li W., Guan K.L. J. Biol. Chem.279:32824-32831(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DSCAM 8. "Phosphoproteomic analysis of the developing mouse brain." Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P. Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Embryonic brain. 9. "Scrib regulates PAK activity during the cell migration process." Nola S., Sebbagh M., Marchetto S., Osmani N., Nourry C., Audebert S., Navarro C., Rachel R., Montcouquiol M., Sans N., Etienne-Manneville S., Borg J.-P., Santoni M.-J. Hum. Mol. Genet.17:3552-3565(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCRIB 10. "Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic beta-Cells." Nie J., Sun C., Faruque O., Ye G., Li J., Liang Q., Chang Z., Yang W., Han X., Shi Y. J. Biol. Chem.287:26435-26444(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BRSK2;PHOSPHORYLATION AT THR-423 11. "Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6." Borroni E.M., Cancellieri C., Vacchini A., Benureau Y., Lagane B., Bachelerie F., Arenzana-Seisdedos F., Mizuno K., Mantovani A., Bonecchi R., Locati M. Sci. Signal.6:RA30-RA30(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION

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