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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Runt-related transcription factor 2

SKU : BHE13810200

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9029m
Alternative Names	Acute myeloid leukemia 3 protein ; Core-binding factor subunit alpha-1 ; CBF-alpha-1 ; Oncogene AML-3 ; Osteoblast-specific transcription factor 2 ; OSF-2 ; Polyomavirus enhancer-binding protein 2 alpha A subunit ; PEA2-alpha A ; SL3-3 enhancer factor 1 alpha A subunit ; SL3/AKV core-binding factor alpha A subunit ; Aml3 ; Cbfa1 ; Osf2 ; Pebp2a
Categories	Elisa
Function	Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Specificity	Natural and recombinant Mouse Runt-related transcription factor 2
Subcellular Location	Nucleus
Detection Range	0.625-40ng/mL
Entryname	RUNX2_MOUSE
Method Type	Sandwich
Platform	PF00853
Protein Name	Runt-related transcription factor 2
Sensitivity	0.32ng/mL
Sequence	50: MLHSPHKQPQ ; NHKCGANFLQ ; EDCKKALAFK ; WLISAGHYQP ; PRPTESVSAL ; 100: TTVHAGIFKA ; ASSIYNRGHK ; FYLEKKGGTM ; ASNSLFSAVT ; PCQQSFFWDP ; 150: STSRRFSPPS ; SSLQPGKMSD ; VSPVVAAQQQ ; QQQQQQQQQQ ; QQQQQQQQQQ ; 200: QQQQQQEAAA ; AAAAAAAAAA ; AAAAAVPRLR ; PPHDNRTMVE ; IIADHPAELV ; 250: RTDSPNFLCS ; VLPSHWRCNK ; TLPVAFKVVA ; LGEVPDGTVV ; TVMAGNDENY ; 300: SAELRNASAV ; MKNQVARFND ; LRFVGRSGRG ; KSFTLTITVF ; TNPPQVATYH ; 350: RAIKVTVDGP ; REPRRHRQKL ; DDSKPSLFSD ; RLSDLGRIPH ; PSMRVGVPPQ ; 400: NPRPSLNSAP ; SPFNPQGQSQ ; ITDPRQAQSS ; PPWSYDQSYP ; SYLSQMTSPS ; 450: IHSTTPLSST ; RGTGLPAITD ; VPRRISDDDT ; ATSDFCLWPS ; SLSKKSQAGA ; 500: SELGPFSDPR ; QFPSISSLTE ; SRFSNPRMHY ; PATFTYTPPV ; TSGMSLGMSA ; 550: TTHYHTYLPP ; PYPGSSQSQS ; GPFQTSSTPY ; LYYGTSSASY ; QFPMVPGGDR ; 600: SPSRMVPPCT ; TTSNGSTLLN ; PNLPNQNDGV ; DADGSHSSSP ; TVLNSSGRMD ; 607: ESVWRPY
Sequence Length	607
String	Q08775
Sub Unit	Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with cyclin B1 CCNB1, KAT6A and KAT6B (By similarity). Interacts with HIVEP3. Interacts with IFI204. Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors. Binds to HIPK3.

Uniprot	Q08775
Gene Name	Runx2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:12393
Unigene	Mm.391013

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810200	E9029m	96T	$776		Add to Cart

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