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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Rho-associated protein kinase 2

SKU : BHE13809714

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1852m
Alternative Names	Rho-associated ; coiled-coil-containing protein kinase 2 ; Rho-associated ; coiled-coil-containing protein kinase II ; ROCK-II ; p164 ROCK-2
Categories	Elisa
Function	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK (RPS6KA1) during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays a role in placental homeostasis during the perinatal period.
Specificity	Natural and recombinant Mouse Rho-associated protein kinase 2
Subcellular Location	Isoform 2 Cytoplasm Cell membrane Peripheral membrane protein
Detection Range	1.56-100ng/mL
Entryname	ROCK2_MOUSE
Method Type	Sandwich
Platform	PF02185
Protein Name	Rho-associated protein kinase 2
Sensitivity	0.78ng/mL
Sequence	50: MSRPPPTGKM ; PGAPEAAPGD ; GAGAGRQRKL ; EALIRDPRSP ; INVESLLDGL ; 100: NSLVLDLDFP ; ALRKNKNIDN ; FLNRYEKIVK ; KIRGLQMKAE ; DYDVVKVIGR ; 150: GAFGEVQLVR ; HKASQKVYAM ; KLLSKFEMIK ; RSDSAFFWEE ; RDIMAFANSP ; 200: WVVQLFCAFQ ; DDRYLYMVME ; YMPGGDLVNL ; MSNYDVPEKW ; AKFYTAEVVL ; 250: ALDAIHSMGL ; IHRDVKPDNM ; LLDKHGHLKL ; ADFGTCMKMD ; ETGMVHCDTA ; 300: VGTPDYISPE ; VLKSQGGDGY ; YGRECDWWSV ; GVFLFEMLVG ; DTPFYADSLV ; 350: GTYSKIMDHK ; NSLCFPEDTE ; ISKHAKNLIC ; AFLTDREVRL ; GRNGVEEIKQ ; 400: HPFFKNDQWN ; WDNIRETAAP ; VVPELSSDID ; SSNFDDIEDD ; KGDVETFPIP ; 450: KAFVGNQLPF ; IGFTYFRENL ; LLSDSPPCRE ; NDAIQTRKSE ; ESQEIQKKLY ; 500: ALEEHLSSEV ; QAKEELEQKC ; KSINTRLEKT ; AKELEEEITL ; RKSVESTLRQ ; 550: LEREKALLQH ; KNAEYQRKAD ; HEADKKRNLE ; NDVNSLKDQL ; EDLKKRNQSS ; 600: QISTEKVNQL ; QKQLDEANAL ; LRTESDTAAR ; LRKTQAESSK ; QIQQLESNNR ; 650: DLQDKNCLLE ; TAKLKLEKEF ; INLQSALESE ; RRDRTHGSEI ; INDLQGRISG ; 700: LEEDLKTGKA ; LLAKVELEKR ; QLQEKLTDLE ; KEKSNMEIDM ; TYQLKVIQQS ; 750: LEQEEAEHKT ; TKARLADKNK ; IYESIEEAKS ; EAMKEMEKKL ; LEERSLKQKV ; 800: ENLLLEAEKR ; CSILDCDLKQ ; SQQKLNELLK ; QKDVLNEDVR ; NLTLKIEQET ; 850: QKRCLMQNDL ; KMQTQQVNTL ; KMSEKQIKQE ; NNHLMEMKMN ; LEKQNTELRK ; 900: ERQDADGQMK ; ELQDQLEAEQ ; YFSTLYKTQV ; RELKEENEEK ; TKLCKELQQK ; 950: KQDLQDERDS ; LAAQLEITLT ; KADSEQLARS ; IAEEQYSDLE ; KEKIMKELEI ; 1000: KEMMARHKQE ; LTEKDTTIAS ; LEETNRTLTS ; DVANLANEKE ; ELNNKLKDSQ ; 1050: EQLSKLKDEE ; MSAAAIKAQF ; EKQLLNERTL ; KTQAVNKLAE ; IMNRKEPVKR ; 1100: GSDTDVRRKE ; KENRKLHMEL ; KSEREKLTQQ ; MIKYQKELNE ; MQAQIAEESQ ; 1150: IRIELQMTLD ; SKDSDIEQLR ; SQLQALHIGM ; DSSSIGSGPG ; DAEPDDGFPE ; 1200: SRLEGWLSLP ; VRNNTKKFGW ; VKKYVIVSSK ; KILFYDSEQD ; KEQSNPYMVL ; 1250: DIDKLFHVRP ; VTQTDVYRAD ; AKEIPRIFQI ; LYANEGESKK ; EPEFPVEPVG ; 1300: EKSNYICHKG ; HEFIPTLYHF ; PTNCEACMKP ; LWHMFKPPPA ; LECRRCHIKC ; 1350: HKDHMDKKEE ; IIAPCKVYYD ; ISSAKNLLLL ; ANSTEEQQKW ; VSRLVKKIPK ; 1388: KPPAPDPFAR ; SSPRTSMKIQ ; QNQSIRRPSR ; QLAPNKPS
Sequence Length	1388
String	P70336
Sub Unit	Homodimer (By similarity). Interacts with RHOA (activated by GTP), CHORDC1, IRS1, RHOB, RHOC, PPP1R12A, SORL1, EP300 and BRCA2 (By similarity). Interacts with NPM1 and this interaction enhances its activity.

Uniprot	P70336
Gene Name	Rock2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:19878
Unigene	Mm.276024

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809714	E1852m	96T	$776		Add to Cart

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