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ELISA Kit for Mouse Retinoic acid receptor RXR-alpha

SKU : BHE13809099

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2043m
Alternative Names	Nuclear receptor subfamily 2 group B member 1 ; Retinoid X receptor alpha ; Nr2b1
Categories	Elisa
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.
Specificity	Natural and recombinant Mouse Retinoic acid receptor RXR-alpha
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	RXRA_MOUSE
Method Type	Sandwich
Platform	PF00104
Protein Name	Retinoic acid receptor RXR-alpha
Sensitivity	0.083ng/mL
Sequence	50: MDTKHFLPLD ; FSTQVNSSSL ; NSPTGRGSMA ; VPSLHPSLGP ; GIGSPLGSPG ; 100: QLHSPISTLS ; SPINGMGPPF ; SVISSPMGPH ; SMSVPTTPTL ; GFGTGSPQLN ; 150: SPMNPVSSTE ; DIKPPLGLNG ; VLKVPAHPSG ; NMASFTKHIC ; AICGDRSSGK ; 200: HYGVYSCEGC ; KGFFKRTVRK ; DLTYTCRDNK ; DCLIDKRQRN ; RCQYCRYQKC ; 250: LAMGMKREAV ; QEERQRGKDR ; NENEVESTSS ; ANEDMPVEKI ; LEAELAVEPK ; 300: TETYVEANMG ; LNPSSPNDPV ; TNICQAADKQ ; LFTLVEWAKR ; IPHFSELPLD ; 350: DQVILLRAGW ; NELLIASFSH ; RSIAVKDGIL ; LATGLHVHRN ; SAHSAGVGAI ; 400: FDRVLTELVS ; KMRDMQMDKT ; ELGCLRAIVL ; FNPDSKGLSN ; PAEVEALREK ; 450: VYASLEAYCK ; HKYPEQPGRF ; AKLLLRLPAL ; RSIGLKCLEH ; LFFFKLIGDT ; 467: PIDTFLMEML ; EAPHQAT
Sequence Length	467
String	P28700
Sub Unit	Homodimer (By similarity). Heterodimer with RARA; required for ligand-dependent retinoic acid receptor transcriptional activity. Heterodimer with PPARA (via the leucine-like zipper in the LBD); the interaction is required for PPARA transcriptional activity. Also heterodimerizes with PPARG (By similarity). Interacts with coactivator NCOA3, PELP1, SENP6, SFPQ, DNTTIP2 and RNF8. Interacts with PRMT2 (By similarity). Interacts with coactivator NCOA6, and FAM120B.

Uniprot	P28700
Gene Name	Rxra
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:20181
Unigene	Mm.24624

Reference	1. "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently." Leid M., Kastner P., Lyons R., Nakshatri H., Saunders M., Zacharewsi T., Chen J.Y., Staub A., Garnier J.-M., Mader S., Chambon P. Cell68:377-395(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];HETERODIMERIZATION WITH RARA;FUNCTION 2. "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid." Mangelsdorf D.J., Borgmeyer U., Heyman R.A., Zhou J.Y., Ong E.S., Oro A.E., Kakizuka A., Evans R.M. Genes Dev.6:329-344(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION OF LIGAND 3. "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha." Tontonoz P., Graves R.A., Budavari A.I., Erdjument-Bromage H., Lui M., Hu E., Tempst P., Spiegelman B.M. Nucleic Acids Res.22:5628-5634(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 5-16; 27-46; 291-307 AND 446-465;SUBUNIT tissue: Adipose tissue. 4. "Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases." Adam-Stitah S., Penna L., Chambon P., Rochette-Egly C. J. Biol. Chem.274:18932-18941(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-22; SER-61; SER-75; THR-87 AND SER-265;FUNCTION;MUTAGENESIS OF SER-22; SER-44; SER-48; SER-54; SER-61; SER-75; THR-87; SER-96; SER-101 AND SER-265 5. "Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR." Zhu Y.-J., Kan L., Qi C., Kanwar Y.S., Yeldandi A.V., Rao M.S., Reddy J.K. J. Biol. Chem.275:13510-13516(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6 6. "The phosphorylation site located in the A region of retinoic X receptor alpha is required for the antiproliferative effect of retinoic acid (RA) and the activation of RA target genes in F9 cells." Bastien J., Adam-Stitah S., Plassat J.L., Chambon P., Rochette-Egly C. J. Biol. Chem.277:28683-28689(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-22;FUNCTION;MUTAGENESIS OF SER-22 7. "Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor." Cho Y.S., Kim E.J., Park U.H., Sin H.S., Um S.J. J. Biol. Chem.281:17588-17598(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ASXL1 AND NCOA1;MUTAGENESIS OF 455-PHE-LEU-456 AND 459-MET-LEU-460 8. "Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis." Li D., Kang Q., Wang D.-M. Mol. Endocrinol.21:2320-2333(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAM120B 9. "Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains." Bourguet W., Vivat V., Wurtz J.M., Chambon P., Gronemeyer H., Moras D. Mol. Cell5:289-298(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 230-462 OF MUTANT ALA-318 IN COMPLEX WITH H.SAPIENS RARA 10. "Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies." Pogenberg V., Guichou J.F., Vivat-Hannah V., Kammerer S., Perez E., Germain P., de Lera A.R., Gronemeyer H., Royer C.A., Bourguet W. J. Biol. Chem.280:1625-1633(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 230-467 IN COMPLEX WITH RARB AND MED1

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