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ELISA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 1

SKU : BHE13810395

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15191m
Antigen	Ripk1
Alternative Names	Cell death protein RIP ; Receptor-interacting protein 1 ; RIP-1 ; Serine/threonine-protein kinase RIP ; Rinp ; Rip
Categories	Elisa
Function	Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.
Specificity	Natural and recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1
Subcellular Location	Cytoplasm Cell membrane
Entryname	RIPK1_MOUSE
Platform	PF00531
Protein Name	Receptor-interacting serine/threonine-protein kinase 1
Sequence	50: MQPDMSLDNI ; KMASSDLLEK ; TDLDSGGFGK ; VSLCYHRSHG ; FVILKKVYTG ; 100: PNRAEYNEVL ; LEEGKMMHRL ; RHSRVVKLLG ; IIIEEGNYSL ; VMEYMEKGNL ; 150: MHVLKTQIDV ; PLSLKGRIIV ; EAIEGMCYLH ; DKGVIHKDLK ; PENILVDRDF ; 200: HIKIADLGVA ; SFKTWSKLTK ; EKDNKQKEVS ; STTKKNNGGT ; LYYMAPEHLN ; 250: DINAKPTEKS ; DVYSFGIVLW ; AIFAKKEPYE ; NVICTEQFVI ; CIKSGNRPNV ; 300: EEILEYCPRE ; IISLMERCWQ ; AIPEDRPTFL ; GIEEEFRPFY ; LSHFEEYVEE ; 350: DVASLKKEYP ; DQSPVLQRMF ; SLQHDCVPLP ; PSRSNSEQPG ; SLHSSQGLQM ; 400: GPVEESWFSS ; SPEYPQDEND ; RSVQAKLQEE ; ASYHAFGIFA ; EKQTKPQPRQ ; 450: NEAYNREEER ; KRRVSHDPFA ; QQRARENIKS ; AGARGHSDPS ; TTSRGIAVQQ ; 500: LSWPATQTVW ; NNGLYNQHGF ; GTTGTGVWYP ; PNLSQMYSTY ; KTPVPETNIP ; 550: GSTPTMPYFS ; GPVADDLIKY ; TIFNSSGIQI ; GNHNYMDVGL ; NSQPPNNTCK ; 600: EESTSRHQAI ; FDNTTSLTDE ; HLNPIRENLG ; RQWKNCARKL ; GFTESQIDEI ; 650: DHDYERDGLK ; EKVYQMLQKW ; LMREGTKGAT ; VGKLAQALHQ ; CCRIDLLNHL ; 656: IRASQS
Sequence Length	656
String	Q60855
Sub Unit	Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif); this interaction induces RIPK1 necroptosis-specific phosphorylation, formation of the necroptosis-inducing complex. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1 (By similarity). Interacts (via RIP homotypic interaction motif) with murid herpesvirus 1 viral inhibitor of RIP activation; this interaction inhibits RIPK1 ubiquitination.

Uniprot	Q60855
Gene Name	Ripk1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:19766
Unigene	Mm.374799

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810395	E15191m	96T	$776		Add to Cart

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