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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Ragulator complex protein LAMTOR5

SKU : BHE13806612

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1313m
Alternative Names	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 ; Hbxip ; Xip
Categories	Elisa
Function	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway.
Specificity	Natural and recombinant Mouse Ragulator complex protein LAMTOR5
Subcellular Location	Cytoplasm Lysosome
Detection Range	1.56-100ng/mL
Entryname	LTOR5_MOUSE
Method Type	Sandwich
Protein Name	Ragulator complex protein LAMTOR5
Sensitivity	0.68ng/mL
Sequence	50: MEATLEQHLE ; DTMKNPSIVG ; VLCTDSQGLN ; LGCRGTLSDE ; HAGVISVLAQ ; 91: QAARLTSDPT ; DIPVVCLESD ; NGNIMIQKHD ; GITVAVHKMA ; S
Sequence Length	91
Sub Unit	Homodimer (Probable). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently.

Uniprot	Q9D1L9
Gene Name	Lamtor5
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:68576
Unigene	Mm.290035

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806612	E1313m	96T	$776		Add to Cart

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