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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Protein S100-A8

SKU : BHE13810096

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1792m
Alternative Names	Calgranulin-A ; Chemotactic cytokine CP-10 ; Leukocyte L1 complex light chain ; Migration inhibitory factor-related protein 8 ; MRP-8 ; Pro-inflammatory S100 cytokine ; S100 calcium-binding protein A8 ; Caga ; Mrp8
Categories	Elisa
Function	Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). Promotes tubulin. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions (By similarity). Has maximal chemotactic activity for neutrophils. May play an important role in cellular immune reactions.
Specificity	Natural and recombinant Mouse Protein S100-A8
Subcellular Location	Secreted Cytoplasm Cytoplasm cytoskeleton Cell membrane Peripheral membrane protein Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes.
Detection Range	0.625-40ng/mL
Entryname	S10A8_MOUSE
Method Type	Sandwich
Platform	PF00036
Protein Name	Protein S100-A8
Sensitivity	0.334ng/mL
Sequence	50: MPSELEKALS ; NLIDVYHNYS ; NIQGNHHALY ; KNDFKKMVTT ; ECPQFVQNIN ; 89: IENLFRELDI ; NSDNAINFEE ; FLAMVIKVGV ; ASHKDSHKE
Sequence Length	89
String	P27005
Sub Unit	Homodimer. Heterotetramer with S100A9. Component of the heterotetrameric calprotectin complex containing two copies each of S100A8 and S100A9. Interacts with AGER and with the heterodimeric complex formed by TLR4 and LY96. Interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin interacts with ANXA6 and associates with tubulin filaments in activated monocytes. May interact with components of the intermediate filaments in monocytes and epithelial cells.

Uniprot	P27005
Gene Name	S100a8
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:20201
Unigene	Mm.21567

Reference	1. "Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage." Lagasse E., Weissman I.L. Blood79:1907-1915(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: BALB/c. 2. "Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10." Lackmann M., Rajasekariah P., Iismaa S.E., Jones G., Cornish C.J., Hu S., Simpson R.J., Moritz R.L., Geczy C.L. J. Immunol.150:2981-2991(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "Molecular characterisation of the genomic locus of the mouse MRP8 gene." Nacken W.K.F., Manitz M.P., Sorg C. Biochim. Biophys. Acta1315:1-5(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] strain: 129/SvJ. tissue: Liver. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: C57BL/6J. tissue: Mammary gland. 5. "Purification and structural analysis of a murine chemotactic cytokine (CP-10) with sequence homology to S100 proteins." Lackmann M., Cornish C.J., Simpson R.J., Moritz R.L., Geczy C.L. J. Biol. Chem.267:7499-7504(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-77 tissue: Spleen. 6. "A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo." Passey R.J., Williams E., Lichanska A.M., Wells C., Hu S., Geczy C.L., Little M.H., Hume D.A. J. Immunol.163:2209-2216(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 7. "Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock." Vogl T., Tenbrock K., Ludwig S., Leukert N., Ehrhardt C., van Zoelen M.A.D., Nacken W., Foell D., van der Poll T., Sorg C., Roth J. Nat. Med.13:1042-1049(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;SUBUNIT;INTERACTION WITH TLR4 AND LY96 8. "S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products." Boyd J.H., Kan B., Roberts H., Wang Y., Walley K.R. Circ. Res.102:1239-1246(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AGER AND ATP2A2 9. "S-nitrosylated S100A8: novel anti-inflammatory properties." Lim S.Y., Raftery M., Cai H., Hsu K., Yan W.X., Hseih H.L., Watts R.N., Richardson D., Thomas S., Perry M., Geczy C.L. J. Immunol.181:5627-5636(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION AT CYS-42 10. "Anti-infective protective properties of S100 calgranulins." Hsu K., Champaiboon C., Guenther B.D., Sorenson B.S., Khammanivong A., Ross K.F., Geczy C.L., Herzberg M.C. Antiinflamm. Antiallergy Agents Med. Chem.8:290-305(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW 11. "Inflammation-associated S100 proteins: new mechanisms that regulate function." Goyette J., Geczy C.L. Amino Acids41:821-842(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW

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