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ELISA Kit for Mouse Prolyl endopeptidase FAP

SKU : BHE13808200

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9685m
Alternative Names	Dipeptidyl peptidase FAP ; 3.4.14.5 ; Fibroblast activation protein alpha ; FAPalpha ; Gelatine degradation protease FAP ; 3.4.21.- ; Integral membrane serine protease ; Post-proline cleaving enzyme ; Serine integral membrane protease ; SIMP ; Surface-expressed protease ; Seprase
Categories	Elisa
Function	In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (By similarity). May have a role in tissue remodeling during development and wound healing, and contribute to invasiveness in malignant cancers.
Specificity	Natural and recombinant Mouse Prolyl endopeptidase FAP
Subcellular Location	Cell membrane Single-pass type II membrane protein Cell projection lamellipodium membrane Single-pass type II membrane protein Cell projection invadopodium membrane Single-pass type II membrane protein Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma.
Detection Range	0.156-10ng/mL
Entryname	SEPR_MOUSE
Method Type	Sandwich
Platform	PF00930
Protein Name	Prolyl endopeptidase FAP
Sensitivity	0.06ng/mL
Sequence	50: MKTWLKTVFG ; VTTLAALALV ; VICIVLRPSR ; VYKPEGNTKR ; ALTLKDILNG ; 100: TFSYKTYFPN ; WISEQEYLHQ ; SEDDNIVFYN ; IETRESYIIL ; SNSTMKSVNA ; 150: TDYGLSPDRQ ; FVYLESDYSK ; LWRYSYTATY ; YIYDLQNGEF ; VRGYELPRPI ; 200: QYLCWSPVGS ; KLAYVYQNNI ; YLKQRPGDPP ; FQITYTGREN ; RIFNGIPDWV ; 250: YEEEMLATKY ; ALWWSPDGKF ; LAYVEFNDSD ; IPIIAYSYYG ; DGQYPRTINI ; 300: PYPKAGAKNP ; VVRVFIVDTT ; YPHHVGPMEV ; PVPEMIASSD ; YYFSWLTWVS ; 350: SERVCLQWLK ; RVQNVSVLSI ; CDFREDWHAW ; ECPKNQEHVE ; ESRTGWAGGF ; 400: FVSTPAFSQD ; ATSYYKIFSD ; KDGYKHIHYI ; KDTVENAIQI ; TSGKWEAIYI ; 450: FRVTQDSLFY ; SSNEFEGYPG ; RRNIYRISIG ; NSPPSKKCVT ; CHLRKERCQY ; 500: YTASFSYKAK ; YYALVCYGPG ; LPISTLHDGR ; TDQEIQVLEE ; NKELENSLRN ; 550: IQLPKVEIKK ; LKDGGLTFWY ; KMILPPQFDR ; SKKYPLLIQV ; YGGPCSQSVK ; 600: SVFAVNWITY ; LASKEGIVIA ; LVDGRGTAFQ ; GDKFLHAVYR ; KLGVYEVEDQ ; 650: LTAVRKFIEM ; GFIDEERIAI ; WGWSYGGYVS ; SLALASGTGL ; FKCGIAVAPV ; 700: SSWEYYASIY ; SERFMGLPTK ; DDNLEHYKNS ; TVMARAEYFR ; NVDYLLIHGT ; 750: ADDNVHFQNS ; AQIAKALVNA ; QVDFQAMWYS ; DQNHGISSGR ; SQNHLYTHMT ; 761: HFLKQCFSLS ; D
Sequence Length	761
String	P97321
Sub Unit	Homodimer, or heterodimer with DPP4. The monomer is inactive.

Uniprot	P97321
Gene Name	Fap
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:14089
Unigene	Mm.41816

Reference	1. "Mouse fibroblast activation protein: molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers." Niedermeyer J., Scanlan M.J., Garin-Chesa P., Daiber C., Fiebig H.H., Old L.J., Rettig W.J., Schnapp A. Int. J. Cancer71:383-389(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3) strain: BALB/c. tissue: Embryo. 2. "Mouse fibroblast-activation protein--conserved Fap gene organization and biochemical function as a serine protease." Niedermeyer J., Enenkel B., Park J.E., Lenter M., Rettig W.J., Damm K., Schnapp A. Eur. J. Biochem.254:650-654(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];FUNCTION;CATALYTIC ACTIVITY 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) tissue: Mammary gland. 4. "Targeted disruption of mouse fibroblast activation protein." Niedermeyer J., Kriz M., Hilberg F., Garin-Chesa P., Bamberger U., Lenter M.C., Park J., Viertel B., Puschner H., Mauz M., Rettig W.J., Schnapp A. Mol. Cell. Biol.20:1089-1094(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;CATALYTIC ACTIVITY;DEVELOPMENTAL STAGE 5. "Expression of the fibroblast activation protein during mouse embryo development." Niedermeyer J., Garin-Chesa P., Kriz M., Hilberg F., Mueller E., Bamberger U., Rettig W.J., Schnapp A. Int. J. Dev. Biol.45:445-447(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;DEVELOPMENTAL STAGE 6. "FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor." Ramirez-Montagut T., Blachere N.E., Sviderskaya E.V., Bennett D.C., Rettig W.J., Garin-Chesa P., Houghton A.N. Oncogene23:5435-5446(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;TISSUE SPECIFICITY;MUTAGENESIS OF SER-624 7. "Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha." Kraman M., Bambrough P.J., Arnold J.N., Roberts E.W., Magiera L., Jones J.O., Gopinathan A., Tuveson D.A., Fearon D.T. Science330:827-830(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY 8. "Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model." Cai F., Li Z., Wang C., Xian S., Xu G., Peng F., Wei Y., Lu Y. BMB Rep.46:252-257(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 9. "Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs." Keane F.M., Yao T.W., Seelk S., Gall M.G., Chowdhury S., Poplawski S.E., Lai J.H., Li Y., Wu W., Farrell P., Vieira de Ribeiro A.J., Osborne B., Yu D.M., Seth D., Rahman K., Haber P., Topaloglu A.K., Wang C., Thomson S., Hennessy A., Prins J., Twigg S.M., McLennan S.V., McCaughan G.W., Bachovchin W.W., Gorrell M.D.more... FEBS Open Bio4:43-54(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY

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