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ELISA Kit for Mouse Prestin

SKU : BHE13810077

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15288m
Alternative Names	Solute carrier family 26 member 5 ; Pres
Categories	Elisa
Function	Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site.
Specificity	Natural and recombinant Mouse Prestin
Subcellular Location	Cell membrane Multi-pass membrane protein Lateral wall of outer hair cells.
Entryname	S26A5_MOUSE
Platform	PF01740
Protein Name	Prestin
Sequence	50: MDHAEENEIP ; AETQRYYVER ; PIFSHPVLQE ; RLHVKDKVTE ; SIGDKLKQAF ; 100: TCTPKKIRNI ; IYMFLPITKW ; LPAYKFKEYV ; LGDLVSGIST ; GVLQLPQGLA ; 150: FAMLAAVPPV ; FGLYSSFYPV ; IMYCFFGTSR ; HISIGPFAVI ; SLMIGGVAVR ; 200: LVPDDIVIPG ; GVNATNGTEA ; RDALRVKVAM ; SVTLLSGIIQ ; FCLGVCRFGF ; 250: VAIYLTEPLV ; RGFTTAAAVH ; VFTSMLKYLF ; GVKTKRYSGI ; FSVVYSTVAV ; 300: LQNVKNLNVC ; SLGVGLMVFG ; LLLGGKEFNE ; RFKEKLPAPI ; PLEFFAVVMG ; 350: TGISAGFNLH ; ESYSVDVVGT ; LPLGLLPPAN ; PDTSLFHLVY ; VDAIAIAIVG ; 400: FSVTISMAKT ; LANKHGYQVD ; GNQELIALGI ; CNSIGSLFQT ; FSISCSLSRS ; 450: LVQEGTGGKT ; QLAGCLASLM ; ILLVILATGF ; LFESLPQAVL ; SAIVIVNLKG ; 500: MFMQFSDLPF ; FWRTSKIELT ; IWLTTFVSSL ; FLGLDYGLIT ; AVIIALLTVI ; 550: YRTQSPSYKV ; LGQLPDTDVY ; IDIDAYEEVK ; EIPGIKIFQI ; NAPIYYANSD ; 600: LYSSALKRKT ; GVNPALIMGA ; RRKAMRKYAK ; EVGNANVANA ; TVVKVDAEVD ; 650: GENATKPEEE ; DDEVKFPPIV ; IKTTFPEELQ ; RFLPQGENVH ; TVILDFTQVN ; 700: FVDSVGVKTL ; AGIVKEYGDV ; GIYVYLAGCS ; PQVVNDLTRN ; NFFENPALKE ; 744: LLFHSIHDAV ; LGSQVREAMA ; EQEATASLPQ ; EDMEPNATPT ; TPEA
Sequence Length	744
String	Q99NH7

Uniprot	Q99NH7
Gene Name	Slc26a5
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:80979
Unigene	Mm.160370

Reference	1. "Expression of prestin, a membrane motor protein, in the mammalian auditory and vestibular periphery." Dougherty G.W., Kachar B. Hear. Res.184:27-40(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/6. tissue: Organ of Corti. 2. "Genomic characterization and expression of mouse prestin, the motor protein of outer hair cells." Zheng J., Long K.B., Matsuda K., Madison L.D., Ryan A., Dallos P.D. Mamm. Genome14:87-96(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY strain: CBA/CaJ. 3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (2005-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810077	E15288m	96T	$776		Add to Cart

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