May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
Specificity
Natural and recombinant Mouse Podoplanin
Subcellular Location
Membrane Single-pass type I membrane protein Cell projection lamellipodium membrane Single-pass type I membrane protein Cell projection filopodium membrane Single-pass type I membrane protein Cell projection microvillus membrane Single-pass type I membrane protein Cell projection ruffle membrane Single-pass type I membrane protein Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.