Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis.
Specificity
Natural and recombinant Mouse Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Homooligomer (By similarity). Binds MYBBP1A, which inhibits transcriptional activation by this protein. Interacts with LRPPRC (By similarity). Interacts with PRDM16. Interacts with LPIN1.