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ELISA Kit for Mouse Period circadian protein homolog 3

SKU : BHE13809280

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15355m
Alternative Names	Circadian clock protein PERIOD 3
Categories	Elisa
Function	Component of the circadian clock mechanism which is essential for generating circadian rhythms. Function unknown.
Specificity	Natural and recombinant Mouse Period circadian protein homolog 3
Subcellular Location	Cytoplasm Nucleus Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS.
Detection Range	0.78-50ng/mL
Entryname	PER3_MOUSE
Method Type	Sandwich
Platform	PF08447
Protein Name	Period circadian protein homolog 3
Sensitivity	0.402ng/mL
Sequence	50: MDPCGDPAVP ; GGDCPQTRGP ; GLQGASGQEG ; PLQGTCVDSS ; HSEHEDRNRM ; 100: SEELIMVVQE ; MKKYFPAERH ; TKPSTLDALN ; YALRCVHSVQ ; ANSDFFQSLG ; 150: PRGAHQADVT ; VYSLEDLTAL ; ASEHTSKNTD ; TFAAVFSFLS ; GRLVHISEQA ; 200: ALILNSKRGF ; LKSVHFVDLL ; APQDVRAFYA ; HTAPTQLPFW ; NNWTQRASQY ; 250: ECAPAKPFFC ; RICGGGDREK ; RHYSPFRILP ; YLVHVHSSAQ ; PEPEPCCLTL ; 300: VEKIHSGYEA ; PRIPVDKRIF ; TTTHTPGCVF ; LEVDERAVPL ; LGYLPQDLIG ; 350: TSILTYLHPE ; DRPLMVAIHQ ; KVLKYAGHPP ; FEHSPVRFCT ; QNGEYVILDS ; 400: SWSSFVNPWS ; RKVSFIIGRH ; KVRTSPLNED ; VFATRIKKAA ; SNDKDIAELQ ; 450: EQIHKLLLQP ; VHASASSGYG ; SLGSSGSQEQ ; HVSITSSSES ; SGHCPEEGQH ; 500: EQMTLQQVYA ; SVNKIKNVGQ ; QLYIESMARS ; SVKPVAETCV ; EPQGGDEQKD ; 550: FSSSQTLKNK ; STTDTGSGGN ; LQQEQPSSSY ; QQMNCIDSVI ; RYLTSYSLPA ; 600: LKRKCISCTN ; TSSSSEEAKP ; IPEVDSSQRD ; TEQLLDIRKQ ; ETTGPSTDIE ; 650: GGAARTLSTA ; ALSVASGISQ ; CSCSSTSGHA ; PPLQSESVAV ; ACKPWALRTK ; 700: ASHLAAGGFK ; HVGLTAAVLS ; AHTQKEEQNY ; VDRFREKILT ; SPYGCYLQQE ; 750: SRNRAQYSCV ; QAGSTAKHSR ; CAGSERQKHK ; RKKLPAPVDT ; SSPGAHLCPH ; 800: VTGLLPDEQH ; WGPSASPSPL ; GAGLAFPSAL ; VVPSQTPYLL ; PSFPLQDMAS ; 850: QGVGVSAAWG ; AAAGCPPLSA ; GPQAVAAFPS ; AYVDTLMTIF ; LHNAPLFPLW ; 900: PPSFSPYPSL ; GAAGSSELAP ; LVPAMAPNPE ; PTTSGHSQRR ; VEENWEAHSE ; 950: ELPFISSRSS ; SPLQLNLLQE ; EMPAPSESAD ; AVRRGAGPDA ; KHHCVTGPSG ; 1000: SRSRHCTSGE ; LATATAQQES ; AAASGSSASS ; IYFSSTDYAS ; EVSENRQRPQ ; 1050: DRQRDEALPG ; AAEESIWRMI ; ERTPECVLMT ; YQVPERGREE ; VLKQDLEKLQ ; 1100: SMEQQQPLFS ; PAQREELAKV ; RSWIHSHTAP ; QEGHLQSCVA ; CEDRGSVGDT ; 1113: AEVLEQHPAE ; DTS
Sequence Length	1113
String	O70361
Sub Unit	Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1, PER2, CRY1, CRY2, and TIMELESS. Interaction with CSNK1D or CSKN1E promotes nuclear location of PER proteins.

Uniprot	O70361
Gene Name	Per3
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:18628
Unigene	Mm.121361

Reference	1. "Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain." Zylka M.J., Shearman L.P., Weaver D.R., Reppert S.M. Neuron20:1103-1110(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION strain: C57BL/6. tissue: Brain. 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. "mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop." Kume K., Zylka M.J., Sriram S., Shearman L.P., Weaver D.R., Jin X., Maywood E.S., Hastings M.H., Reppert S.M. Cell98:193-205(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMODIMERIZATION;INTERACTION WITH PER1; PER2; CRY1 AND CRY2;SUBCELLULAR LOCATION 4. "Nuclear export of mammalian PERIOD proteins." Vielhaber E.L., Duricka D., Ullman K.S., Virshup D.M. J. Biol. Chem.276:45921-45927(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;NUCLEAR EXPORT SIGNAL 5. "Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock." Bae K., Jin X., Maywood E.S., Hastings M.H., Reppert S.M., Weaver D.R. Neuron30:525-536(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CIRCADIAN RHYTHMS;DISRUPTION PHENOTYPE 6. "Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells." Akashi M., Tsuchiya Y., Yoshino T., Nishida E. Mol. Cell. Biol.22:1693-1703(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSNK1D AND CSNK1E;PHOSPHORYLATION;UBIQUITINATION;SUBCELLULAR LOCATION 7. "Requirement of mammalian Timeless for circadian rhythmicity." Barnes J.W., Tischkau S.A., Barnes J.A., Mitchell J.W., Burgoon P.W., Hickok J.R., Gillette M.U. Science302:439-442(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TIMELESS;INDUCTION 8. "Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock." Lee C., Weaver D.R., Reppert S.M. Mol. Cell. Biol.24:584-594(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PER1; PER2; CRY1 AND CRY2;PHOSPHORYLATION;SUBCELLULAR LOCATION;INDUCTION;TISSUE SPECIFICITY 9. "SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein." Shirogane T., Jin J., Ang X.L., Harper J.W. J. Biol. Chem.280:26863-26872(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FBXW11 AND BTRC;MUTAGENESIS OF 613-S--S-627 10. "Altered sleep and behavioral activity phenotypes in PER3-deficient mice." Hasan S., van der Veen D.R., Winsky-Sommerer R., Dijk D.J., Archer S.N. Am. J. Physiol.301:R1821-R1830(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SLEEP HOMEOSTASIS;DISRUPTION PHENOTYPE 11. "Metabolism and the circadian clock converge." Eckel-Mahan K., Sassone-Corsi P. Physiol. Rev.93:107-135(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW 12. "Molecular architecture of the mammalian circadian clock." Partch C.L., Green C.B., Takahashi J.S. Trends Cell Biol.24:90-99(2014) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW 13. "Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function." Kucera N., Schmalen I., Hennig S., Ollinger R., Strauss H.M., Grudziecki A., Wieczorek C., Kramer A., Wolf E. Proc. Natl. Acad. Sci. U.S.A.109:3311-3316(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 108-411;FUNCTION IN HEME BINDING;SUBUNIT;MUTAGENESIS OF TRP-359 AND ILE-367

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