CD62 antigen-like family member P ; Granule membrane protein 140 ; GMP-140 ; Leukocyte-endothelial cell adhesion molecule 3 ; LECAM3 ; Platelet activation dependent granule-external membrane protein ; PADGEM ; CD62P ; Grmp
Categories
Elisa
Function
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.