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ELISA Kit for Mouse Neurogenic locus notch homolog protein 2

SKU : BHE13808974

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2420m
Alternative Names	Motch B
Categories	Elisa
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.
Specificity	Natural and recombinant Mouse Neurogenic locus notch homolog protein 2
Subcellular Location	Notch 2 intracellular domain Nucleus Following proteolytical processing NICD is translocated to the nucleus.
Detection Range	0.156-10ng/mL
Entryname	NOTC2_MOUSE
Method Type	Sandwich
Platform	PF00023
Protein Name	Neurogenic locus notch homolog protein 2
Sensitivity	0.088ng/mL
Sequence	50: MPDLRPAALR ; ALLWLWLCGA ; GPAHALQCRG ; GQEPCVNEGT ; CVTYHNGTGF ; 100: CRCPEGFLGE ; YCQHRDPCEK ; NRCQNGGTCV ; PQGMLGKATC ; RCAPGFTGED ; 150: CQYSTSHPCF ; VSRPCQNGGT ; CHMLSRDTYE ; CTCQVGFTGK ; QCQWTDACLS ; 200: HPCENGSTCT ; SVASQFSCKC ; PAGLTGQKCE ; ADINECDIPG ; RCQHGGTCLN ; 250: LPGSYRCQCG ; QGFTGQHCDS ; PYVRGLPCVN ; GGTCRQTGDF ; TLECNCLPGF ; 300: EGSTCERNID ; DCPNHKCQNG ; GVCVDGVNTY ; NCRCPPQWTG ; QFCTEDVDEC ; 350: LLQPNACQNG ; GTCTNRNGGY ; GCVCVNGWSG ; DDCSENIDDC ; AYASCTPGST ; 400: CIDRVASFSC ; LCPEGKAGLL ; CHLDDACISN ; PCHKGALCDT ; NPLNGQYICT ; 450: CPQGYKGADC ; TEDVDECAMA ; NSNPCEHAGK ; CVNTDGAFHC ; ECLKGYAGPR ; 500: CEMDINECHS ; DPCQNDATCL ; DKIGGFTCLC ; MPGFKGVHCE ; LEVNECQSNP ; 550: CVNNGQCVDK ; VNRFQCLCPP ; GFTGPVCQID ; IDDCSSTPCL ; NGAKCIDHPN ; 600: GYECQCATGF ; TGILCDENID ; NCDPDPCHHG ; QCQDGIDSYT ; CICNPGYMGA ; 650: ICSDQIDECY ; SSPCLNDGRC ; IDLVNGYQCN ; CQPGTSGLNC ; EINFDDCASN ; 700: PCMHGVCVDG ; INRYSCVCSP ; GFTGQRCNID ; IDECASNPCR ; KGATCINDVN ; 750: GFRCICPEGP ; HHPSCYSQVN ; ECLSNPCIHG ; NCTGGLSGYK ; CLCDAGWVGV ; 800: NCEVDKNECL ; SNPCQNGGTC ; NNLVNGYRCT ; CKKGFKGYNC ; QVNIDECASN ; 850: PCLNQGTCFD ; DVSGYTCHCM ; LPYTGKNCQT ; VLAPCSPNPC ; ENAAVCKEAP ; 900: NFESFSCLCA ; PGWQGKRCTV ; DVDECISKPC ; MNNGVCHNTQ ; GSYVCECPPG ; 950: FSGMDCEEDI ; NDCLANPCQN ; GGSCVDHVNT ; FSCQCHPGFI ; GDKCQTDMNE ; 1000: CLSEPCKNGG ; TCSDYVNSYT ; CTCPAGFHGV ; HCENNIDECT ; ESSCFNGGTC ; 1050: VDGINSFSCL ; CPVGFTGPFC ; LHDINECSSN ; PCLNAGTCVD ; GLGTYRCICP ; 1100: LGYTGKNCQT ; LVNLCSRSPC ; KNKGTCVQEK ; ARPHCLCPPG ; WDGAYCDVLN ; 1150: VSCKAAALQK ; GVPVEHLCQH ; SGICINAGNT ; HHCQCPLGYT ; GSYCEEQLDE ; 1200: CASNPCQHGA ; TCNDFIGGYR ; CECVPGYQGV ; NCEYEVDECQ ; NQPCQNGGTC ; 1250: IDLVNHFKCS ; CPPGTRGLLC ; EENIDECAGG ; PHCLNGGQCV ; DRIGGYTCRC ; 1300: LPGFAGERCE ; GDINECLSNP ; CSSEGSLDCV ; QLKNNYNCIC ; RSAFTGRHCE ; 1350: TFLDVCPQKP ; CLNGGTCAVA ; SNMPDGFICR ; CPPGFSGARL ; QSSCGQVKCR ; 1400: RGEQCIHTDS ; GPRCFCLNPK ; DCESGCASNP ; CQHGGTCYPQ ; RQPPHYSCRC ; 1450: PPSFGGSHCE ; LYTAPTSTPP ; ATCQSQYCAD ; KARDGICDEA ; CNSHACQWDG ; 1500: GDCSLTMEDP ; WANCTSTLRC ; WEYINNQCDE ; QCNTAECLFD ; NFECQRNSKT ; 1550: CKYDKYCADH ; FKDNHCDQGC ; NSEECGWDGL ; DCASDQPENL ; AEGTLIIVVL ; 1600: LPPEQLLQDS ; RSFLRALGTL ; LHTNLRIKQD ; SQGALMVYPY ; FGEKSAAMKK ; 1650: QKMTRRSLPE ; EQEQEQEVIG ; SKIFLEIDNR ; QCVQDSDQCF ; KNTDAAAALL ; 1700: ASHAIQGTLS ; YPLVSVFSEL ; ESPRNAQLLY ; LLAVAVVIIL ; FFILLGVIMA ; 1750: KRKQAWLPLA ; AGRFTLRRDS ; SNHKRREPVG ; QDAVGLKNLS ; VQVSEANLIG ; 1800: SGTSEHWVDD ; EGPQPKKAKA ; EDEALLSEDD ; PIDRRPWTQQ ; HLEAADISHT ; 1850: PSLALTPPQA ; EQEVDVLDVN ; VRGPDGCTPL ; MLASLRGGSS ; DLSDEDEDAE ; 1900: DSSANIITDL ; VYQGASLQAQ ; TDRTGEMALH ; LAARYSRADA ; AKRLLDAGAD ; 1950: RNAQDNMGRC ; PLHAAVAGDA ; QGVFQILIRN ; RVTDLDARMN ; DGTTPLILAA ; 2000: RLAVEGMVAE ; LINCQADVNA ; VDDHGKSALH ; WAAAVNNVEA ; TLLLLKNGAN ; 2050: RDMQDNKEET ; PLFLAAREGS ; YEAAKILLDH ; FANRDITDHM ; DRLPRDVARD ; 2100: RMHHDIVRLL ; DEYNVTPSPP ; GTVLTSALSP ; VLCGPNRSFL ; SLKHTPMGKK ; 2150: ARRPNTKSTM ; PTSLPNLAKE ; AKDAKGSRRK ; KCLNEKVQLS ; ESSVTLSPVD ; 2200: SLESPHTYVS ; DATSSPMITS ; PGILQASPTP ; LLAAAAPAAP ; VHTQHALSFS ; 2250: NLHDMQPLAP ; GASTVLPSVS ; QLLSHHHIAP ; PGSSSAGSLG ; RLHPVPVPAD ; 2300: WMNRVEMNET ; QYSEMFGMVL ; APAEGAHPGI ; AAPQSRPPEG ; KHMSTQREPL ; 2350: PPIVTFQLIP ; KRSIAQAAGA ; PQTQSSCPPA ; VAGPLPSMYQ ; IPEMPRLPSV ; 2400: AFPPTMMPQQ ; EGQVAQTIVP ; TYHPFPASVG ; KYPTPPSQHS ; YASSNAAERT ; 2450: PSHGGHLQGE ; HPYLTPSPES ; PDQWSSSSPH ; SASDWSDVTT ; SPTPGGGGGG ; 2470: QRGPGTHMSE ; PPHSNMQVYA ;
Sequence Length	2470
String	O35516
Sub Unit	Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH2. Interacts with RELA/p65.

Uniprot	O35516
Gene Name	Notch2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:18129
Unigene	Mm.485843

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