Divalent cation transporter 1 ; Divalent metal transporter 1 ; DMT-1 ; Solute carrier family 11 member 2 ; Dct1 ; Dmt1 ; Nramp2
Categories
Elisa
Function
Important in metal transport, in particular iron. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution.
Specificity
Natural and recombinant Mouse Natural resistance-associated macrophage protein 2
Forms a complex with NDFIP1 and NEDD4L, in cortical neurons, in response to iron and colbalt exposure; this interaction leads to ubiquitination by NEDD4L and proteasome-dependent degradation. Interacts with NDFIP2.