Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.
Specificity
Natural and recombinant Mouse NADPH oxidase 4
Subcellular Location
Endoplasmic reticulum membrane Multi-pass membrane protein Cell junction focal adhesion Cell membrane May localize to plasma membrane and focal adhesions.