NAD-dependent protein deacetylase. Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex.
Specificity
Natural and recombinant Mouse NAD-dependent deacetylase sirtuin-7
Subcellular Location
Cytoplasm Nucleus nucleolus Located close to the nuclear membrane when in the cytoplasm (By similarity). Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.