DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Specificity
Natural and recombinant Mouse N-glycosylase/DNA lyase
Subcellular Location
Nucleus nucleoplasm Nucleus speckle Nucleus matrix Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.
"Complete genomic DNA sequence of the Mus musculus 8-oxoguanine DNA glycosylase 1 gene (OGH1)." Johnsen B., Luna L., Rognes T., Seeberg E. Submitted (1997-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]