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ELISA Kit for Mouse Mast/stem cell growth factor receptor Kit

SKU : BHE13805975

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0121m
Alternative Names	Proto-oncogene c-Kit ; Tyrosine-protein kinase Kit ; CD117 ; Sl
Categories	Elisa
Function	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
Specificity	Natural and recombinant Mouse Mast/stem cell growth factor receptor Kit
Subcellular Location	Isoform 3 Cytoplasm Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.
Detection Range	0.156-10ng/mL
Entryname	KIT_MOUSE
Method Type	Sandwich
Platform	PF07679
Protein Name	Mast/stem cell growth factor receptor Kit
Sensitivity	0.083ng/mL
Sequence	50: MRGARGAWDL ; LCVLLVLLRG ; QTATSQPSAS ; PGEPSPPSIH ; PAQSELIVEA ; 100: GDTLSLTCID ; PDFVRWTFKT ; YFNEMVENKK ; NEWIQEKAEA ; TRTGTYTCSN ; 150: SNGLTSSIYV ; FVRDPAKLFL ; VGLPLFGKED ; SDALVRCPLT ; DPQVSNYSLI ; 200: ECDGKSLPTD ; LTFVPNPKAG ; ITIKNVKRAY ; HRLCVRCAAQ ; RDGTWLHSDK ; 250: FTLKVRAAIK ; AIPVVSVPET ; SHLLKKGDTF ; TVVCTIKDVS ; TSVNSMWLKM ; 300: NPQPQHIAQV ; KHNSWHRGDF ; NYERQETLTI ; SSARVDDSGV ; FMCYANNTFG ; 350: SANVTTTLKV ; VEKGFINISP ; VKNTTVFVTD ; GENVDLVVEY ; EAYPKPEHQQ ; 400: WIYMNRTSAN ; KGKDYVKSDN ; KSNIRYVNQL ; RLTRLKGTEG ; GTYTFLVSNS ; 450: DASASVTFNV ; YVNTKPEILT ; YDRLINGMLQ ; CVAEGFPEPT ; IDWYFCTGAE ; 500: QRCTTPVSPV ; DVQVQNVSVS ; PFGKLVVQSS ; IDSSVFRHNG ; TVECKASNDV ; 550: GKSSAFFNFA ; FKGNNKEQIQ ; AHTLFTPLLI ; GFVVAAGAMG ; IIVMVLTYKY ; 600: LQKPMYEVQW ; KVVEEINGNN ; YVYIDPTQLP ; YDHKWEFPRN ; RLSFGKTLGA ; 650: GAFGKVVEAT ; AYGLIKSDAA ; MTVAVKMLKP ; SAHLTEREAL ; MSELKVLSYL ; 700: GNHMNIVNLL ; GACTVGGPTL ; VITEYCCYGD ; LLNFLRRKRD ; SFIFSKQEEQ ; 750: AEAALYKNLL ; HSTEPSCDSS ; NEYMDMKPGV ; SYVVPTKTDK ; RRSARIDSYI ; 800: ERDVTPAIME ; DDELALDLDD ; LLSFSYQVAK ; GMAFLASKNC ; IHRDLAARNI ; 850: LLTHGRITKI ; CDFGLARDIR ; NDSNYVVKGN ; ARLPVKWMAP ; ESIFSCVYTF ; 900: ESDVWSYGIF ; LWELFSLGSS ; PYPGMPVDSK ; FYKMIKEGFR ; MVSPEHAPAE ; 950: MYDVMKTCWD ; ADPLKRPTFK ; QVVQLIEKQI ; SDSTKHIYSN ; LANCNPNPEN ; 979: PVVVDHSVRV ; NSVGSSASST ; QPLLVHEDA
Sequence Length	979
String	P05532
Sub Unit	Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU (By similarity). Interacts with the protein kinase FES/FPS. Interacts with PLCG1. Interacts (via phosphorylated tyrosine residues) with PIK3R1.

Uniprot	P05532
Gene Name	Kit
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16590
Unigene	Mm.247073

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805975	E0121m	96T	$776		Add to Cart

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