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ELISA Kit for Mouse Long-chain fatty acid transport protein 1

SKU : BHE13809769

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12692m
Alternative Names	Solute carrier family 27 member 1 ; Fatp ; Fatp1
Categories	Elisa
Function	Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FatP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids.
Specificity	Natural and recombinant Mouse Long-chain fatty acid transport protein 1
Subcellular Location	Cell membrane Single-pass membrane protein Endomembrane system Single-pass membrane protein Cytoplasm Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes.
Detection Range	0.312-20ng/mL
Entryname	S27A1_MOUSE
Method Type	Sandwich
Platform	PF00501
Protein Name	Long-chain fatty acid transport protein 1
Sensitivity	0.167ng/mL
Sequence	50: MRAPGAGTAS ; VASLALLWFL ; GLPWTWSAAA ; AFCVYVGGGG ; WRFLRIVCKT ; 100: ARRDLFGLSV ; LIRVRLELRR ; HRRAGDTIPC ; IFQAVARRQP ; ERLALVDASS ; 150: GICWTFAQLD ; TYSNAVANLF ; RQLGFAPGDV ; VAVFLEGRPE ; FVGLWLGLAK ; 200: AGVVAALLNV ; NLRREPLAFC ; LGTSAAKALI ; YGGEMAAAVA ; EVSEQLGKSL ; 250: LKFCSGDLGP ; ESILPDTQLL ; DPMLAEAPTT ; PLAQAPGKGM ; DDRLFYIYTS ; 300: GTTGLPKAAI ; VVHSRYYRIA ; AFGHHSYSMR ; AADVLYDCLP ; LYHSAGNIMG ; 350: VGQCVIYGLT ; VVLRKKFSAS ; RFWDDCVKYN ; CTVVQYIGEI ; CRYLLRQPVR ; 400: DVEQRHRVRL ; AVGNGLRPAI ; WEEFTQRFGV ; PQIGEFYGAT ; ECNCSIANMD ; 450: GKVGSCGFNS ; RILTHVYPIR ; LVKVNEDTME ; PLRDSEGLCI ; PCQPGEPGLL ; 500: VGQINQQDPL ; RRFDGYVSDS ; ATNKKIAHSV ; FRKGDSAYLS ; GDVLVMDELG ; 550: YMYFRDRSGD ; TFRWRGENVS ; TTEVEAVLSR ; LLGQTDVAVY ; GVAVPGVEGK ; 600: AGMAAIADPH ; SQLDPNSMYQ ; ELQKVLASYA ; RPIFLRLLPQ ; VDTTGTFKIQ ; 646: KTRLQREGFD ; PRQTSDRLFF ; LDLKQGRYVP ; LDERVHARIC ; AGDFSL
Sequence Length	646
String	Q60714
Sub Unit	Self-associates. May function as an homodimer.

Uniprot	Q60714
Gene Name	Slc27a1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:26457
Unigene	Mm.38165

Reference	1. "Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein." Schaffer J.E., Lodish H.F. Cell79:427-436(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Swiss. 2. "Characterization of the murine fatty acid transport protein gene and its insulin response sequence." Hui T.Y., Frohnert B.I., Smith A.J., Schaffer J.E., Bernlohr D.A. J. Biol. Chem.273:27420-27429(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: C57BL/6. tissue: Retina. 4. "Substitution of alanine for serine 250 in the murine fatty acid transport protein inhibits long chain fatty acid transport." Stuhlsatz-Krouper S.M., Bennett N.E., Schaffer J.E. J. Biol. Chem.273:28642-28650(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-250 5. "A family of fatty acid transporters conserved from mycobacterium to man." Hirsch D., Stahl A., Lodish H.F. Proc. Natl. Acad. Sci. U.S.A.95:8625-8629(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN FATTY ACID TRANSPORT;TISSUE SPECIFICITY 6. "The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase." Coe N.R., Smith A.J., Frohnert B.I., Watkins P.A., Bernlohr D.A. J. Biol. Chem.274:36300-36304(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN ACYL-COA LIGASE;SUBCELLULAR LOCATION;MUTAGENESIS OF 249-THR--GLY-254 7. "Molecular aspects of fatty acid transport: mutations in the IYTSGTTGXPK motif impair fatty acid transport protein function." Stuhlsatz-Krouper S.M., Bennett N.E., Schaffer J.E. Prostaglandins Leukot. Essent. Fatty Acids60:285-289(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-250 AND THR-252 8. "Membrane topology of the murine fatty acid transport protein 1." Lewis S.E., Listenberger L.L., Ory D.S., Schaffer J.E. J. Biol. Chem.276:37042-37050(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TOPOLOGY 9. "Oligomerization of the murine fatty acid transport protein 1." Richards M.R., Listenberger L.L., Kelly A.A., Lewis S.E., Ory D.S., Schaffer J.E. J. Biol. Chem.278:10477-10483(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OLIGOMERIZATION 10. "Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes." Stahl A., Evans J.G., Pattel S., Hirsch D., Lodish H.F. Dev. Cell2:477-488(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 11. "Characterization of the acyl-CoA synthetase activity of purified murine fatty acid transport protein 1." Hall A.M., Smith A.J., Bernlohr D.A. J. Biol. Chem.278:43008-43013(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN ACYL-COA LIGASE 12. "Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle." Kim J.K., Gimeno R.E., Higashimori T., Kim H.J., Choi H., Punreddy S., Mozell R.L., Tan G., Stricker-Krongrad A., Hirsch D.J., Fillmore J.J., Liu Z.X., Dong J., Cline G., Stahl A., Lodish H.F., Shulman G.I. J. Clin. Invest.113:756-763(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 13. "Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells." Garcia-Martinez C., Marotta M., Moore-Carrasco R., Guitart M., Camps M., Busquets S., Montell E., Gomez-Foix A.M. Am. J. Physiol.288:C1264-C1272(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION 14. "Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast." DiRusso C.C., Li H., Darwis D., Watkins P.A., Berger J., Black P.N. J. Biol. Chem.280:16829-16837(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION

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