ELISA Kit for Mouse Interleukin-23 subunit alpha

Mfr.No.

E0384m

Alternative Names

Interleukin-23 subunit p19 ; IL-23p19

Categories

Elisa

Function

Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Specificity

Natural and recombinant Mouse Interleukin-23 subunit alpha

Subcellular Location

Secreted Secreted upon association with IL12B.

Detection Range

15.6-1000pg/mL

Entryname

IL23A_MOUSE

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of IL23A and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	94-105%	95-103%	96-105%	97-109%
EDTA plasma(n=5)	93-99%	94-105%	92-99%	95-106%
heparin plasma(n=5)	95-104%	94-109%	99-107%	93-108%

Method Type

Sandwich

Platform

PF00489

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤6.1%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤8.2%

Protein Name

Interleukin-23 subunit alpha

Recovery

Recovery was determined by spiking various levels of IL23A into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	101	94-105
Plasma	100	93-106

Sensitivity

7.8pg/mL

Sequence

50:

MLDCRAVIML ; WLLPWVTQGL ; AVPRSSSPDW ; AQCQQLSRNL ; CMLAWNAHAP ;

100:

AGHMNLLREE ; EDEETKNNVP ; RIQCEDGCDP ; QGLKDNSQFC ; LQRIRQGLAF ;

150:

YKHLLDSDIF ; KGEPALLPDS ; PMEQLHTSLL ; GLSQLLQPED ; HPRETQQMPS ;

196:

LSSSQQWQRP ; LLRSKILRSL ; QAFLAIAARV ; FAHGAATLTE ; PLVPTA

Sequence Length

196

String

Q9EQ14

Sub Unit

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.

Uniprot	Q9EQ14
Gene Name	Il23a
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:83430
Unigene	Mm.125482

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805530	E0384m	96T	$776		Add to Cart

ELISA Kit for Mouse Interleukin-23 subunit alpha

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