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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Interleukin-12 subunit beta

SKU : BHE13804720

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0058m
Alternative Names	Cytotoxic lymphocyte maturation factor 40 kDa subunit ; CLMF p40 ; IL-12 subunit p40
Categories	Elisa
Function	Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Specificity	Natural and recombinant Mouse Interleukin-12 subunit beta
Subcellular Location	Secreted
Detection Range	31.2-2000pg/mL
Entryname	IL12B_MOUSE
Method Type	Sandwich
Platform	PF10420
Protein Name	Interleukin-12 subunit beta
Sensitivity	15.68pg/mL
Sequence	50: MCPQKLTISW ; FAIVLLVSPL ; MAMWELEKDV ; YVVEVDWTPD ; APGETVNLTC ; 100: DTPEEDDITW ; TSDQRHGVIG ; SGKTLTITVK ; EFLDAGQYTC ; HKGGETLSHS ; 150: HLLLHKKENG ; IWSTEILKNF ; KNKTFLKCEA ; PNYSGRFTCS ; WLVQRNMDLK ; 200: FNIKSSSSSP ; DSRAVTCGMA ; SLSAEKVTLD ; QRDYEKYSVS ; CQEDVTCPTA ; 250: EETLPIELAL ; EARQQNKYEN ; YSTSFFIRDI ; IKPDPPKNLQ ; MKPLKNSQVE ; 300: VSWEYPDSWS ; TPHSYFSLKF ; FVRIQRKKEK ; MKETEEGCNQ ; KGAFLVEKTS ; 335: TEVQCKGGNV ; CVQAQDRYYN ; SSCSKWACVP ; CRVRS
Sequence Length	335
String	P43432
Sub Unit	Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.

Uniprot	P43432
Gene Name	Il12b
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16160
Unigene	Mm.239707

Reference	1. "Cloning and expression of murine IL-12." Schoenhaut D.S., Chua A.O., Wolitzky A.G., Quinn P.M., Dwyer C.M., Gately M.K., Gubler U. J. Immunol.148:3433-3440(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/6. tissue: Spleen. 2. "Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes." Tone Y., Thompson S.A., Babik J.M., Nolan K.F., Tone M., Raven C., Waldmann H. Eur. J. Immunol.26:1222-1227(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 3. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis." Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P. J. Immunol.163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS THR-169 AND LEU-294 strain: B10.S/J. strain: SJL/J. tissue: Spleen. 4. "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12." Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., Vega F., Yu N., Wang J., Singh K.P., Zonin F., Vaisberg E., Churakova T., Liu M.-R., Gorman D., Wagner J., Zurawski S., Liu Y.-J., Abrams J.S., Moore K.W., Rennick D.M., de Waal-Malefyt R., Hannum C., Bazan J.F., Kastelein R.A.more... Immunity13:715-725(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IL23A

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BHE13804720	E0058m	96T	$776		Add to Cart

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