CD49 antigen-like family member B ; Collagen receptor ; Platelet membrane glycoprotein Ia ; GPIa ; VLA-2 subunit alpha ; CD49b
Categories
Elisa
Function
Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis.