Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP.
Specificity
Natural and recombinant Mouse Insulin-degrading enzyme
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;IDENTIFICATION OF SLYX MOTIF;MUTAGENESIS OF 853-GLU--TYR-858
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-192 AND LYS-697;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]