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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Histone H2AX

SKU : BHE13805342

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15010m
Alternative Names	Histone H2A.X ; H2a.x ; H2ax ; Hist5-2ax
Categories	Elisa
Function	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Specificity	Natural and recombinant Mouse Histone H2AX
Subcellular Location	Nucleus Chromosome
Detection Range	31.2-2000pg/mL
Entryname	H2AX_MOUSE
Method Type	Sandwich
Platform	PF00125
Protein Name	Histone H2AX
Sensitivity	15.61pg/mL
Sequence	50: MSGRGKTGGK ; ARAKAKSRSS ; RAGLQFPVGR ; VHRLLRKGHY ; AERVGAGAPV ; 100: YLAAVLEYLT ; AEILELAGNA ; ARDNKKTRII ; PRHLQLAIRN ; DEELNKLLGG ; 143: VTIAQGGVLP ; NIQAVLLPKK ; SSATVGPKAP ; AVGKKASQAS ; QEY
Sequence Length	143
String	P27661
Sub Unit	The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. May interact with numerous proteins required for DNA damage signaling and repair when phosphorylated on Ser-140. These include MDC1, TP53BP1 and the MRN complex, composed of MRE11A, RAD50, and NBN. Interaction with the MRN complex is likely mediated at least in part by NBN. May also interact with DHX9/NDHII when phosphorylated on Ser-140.

Uniprot	P27661
Gene Name	H2afx
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:15270
Unigene	Mm.245931

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805342	E15010m	96T	$776		Add to Cart

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