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ELISA Kit for Mouse Histidine-rich glycoprotein

SKU : BHE13805458

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2267m
Alternative Names	Histidine-proline-rich glycoprotein ; HPRG
Categories	Elisa
Function	Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in an heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology (By similarity). Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2.
Specificity	Natural and recombinant Mouse Histidine-rich glycoprotein
Subcellular Location	Secreted
Detection Range	31.2-2000pg/mL
Entryname	HRG_MOUSE
Method Type	Sandwich
Platform	PF00031
Protein Name	Histidine-rich glycoprotein
Sensitivity	15.6pg/mL
Sequence	50: MKVLTTALLL ; VTLQCSHALS ; PTNCDASEPL ; AEKVLDLINK ; GRRSGYVFEL ; 100: LRVSDAHLDR ; AGTATVYYLA ; LDVIESDCWV ; LSTKAQDDCL ; PSRWQSEIVI ; 150: GQCKVIATRY ; SNESQDLSVN ; GYNCTTSSVS ; SALRNTKDSP ; VLLDFFEDSE ; 200: LYRKQARKAL ; DKYKTDNGDF ; ASFRVERAER ; VIRARGGERT ; NYYVEFSMRN ; 250: CSTQHFPRSP ; LVFGFCRALL ; SYSIETSDLE ; TPDSIDINCE ; VFNIEDHKDT ; 300: SDMKPHWGHE ; RPLCDKHLCK ; LSGSRDHHHT ; HKTDKLGCPP ; PPEGKDNSDR ; 350: PRLQEGALPQ ; LPPGYPPHSG ; ANRTHRPSYN ; HSCNEHPCHG ; HRPHGHHPHS ; 400: HHPPGHHSHG ; HHPHGHHPHS ; HHSHGHHPPG ; HHPHGHHPHG ; HHPHGHHPHG ; 450: HHPHGHDFLD ; YGPCDPPSNS ; QELKGQYHRG ; YGPPHGHSRK ; RGPGKGLFPF ; 500: HHQQIGYVYR ; LPPLNIGEVL ; TLPEANFPSF ; SLPNCNRSLQ ; PEIQPFPQTA ; 525: SRSCPGKFES ; EFPQISKFFG ; YTPPK
Sequence Length	525
String	Q9ESB3
Sub Unit	Interacts with THBS1 (via the TSP type I repeats); the interaction blocks the antiangiogenic effect of THBS1 with CD36. Interacts with HPSE; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts (via the HRR domain) with TMP1; the interaction partially mediates the antiangiogenic properties of HRG. Interacts with kappa and lambda light chains of IgG molecules. Interacts with ATP5A1; the interaction occurs on the surface of T-cells and alters their cell morphology in concert with CONA. Binds IgG molecules containing kappa and lambda light chains and inhibits the formation of insoluble immunoglobulin complexes. Interacts with F12; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding to HRG, inhibits factor XII autoactivation and contact-initiated coagulation (By similarity). Interacts with PLG (via its Kringle domains); the interaction tethers PLG to the cell surface and enhances its activation. Interacts (via the HRR domain) with TPM1; the interaction appears to contribute to the antiangiogenic properties of the HRR domain (By similarity). Interacts with THBS2; the interaction blocks the antiangiogenic effect of THBS2 with CD36.

Uniprot	Q9ESB3
Gene Name	Hrg
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:94175
Unigene	Mm.358794

Reference	1. "Murine histidine-rich glycoprotein: cloning, characterization and cellular origin." Hulett M.D., Parish C.R. Immunol. Cell Biol.78:280-287(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY strain: 129. 2. "Identification of fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity." Hsu S.J., Nagase H., Balmain A. Genome47:931-946(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] strain: NIH/Ola. 3. "Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG)." Tsuchida-Straeten N., Ensslen S., Schafer C., Woltje M., Denecke B., Moser M., Graber S., Wakabayashi S., Koide T., Jahnen-Dechent W. J. Thromb. Haemost.3:865-872(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DISRUPTION PHENOTYPE;FUNCTION strain: BALB/c. tissue: Liver. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: FVB/N. tissue: Liver. 5. "The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein." Simantov R., Febbraio M., Silverstein R.L. Matrix Biol.24:27-34(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THBS2;FUNCTION 6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides." Bernhard O.K., Kapp E.A., Simpson R.J. J. Proteome Res.6:987-995(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-200 strain: C57BL/6. tissue: Plasma. 7. "Histidine-rich glycoprotein protects from systemic Candida infection." Rydengard V., Shannon O., Lundqvist K., Kacprzyk L., Chalupka A., Olsson A.K., Morgelin M., Jahnen-Dechent W., Malmsten M., Schmidtchen A. PLoS Pathog.4:E1000116-E1000116(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;FUNCTION 8. "Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein." Thulin A., Ringvall M., Dimberg A., Karehed K., Vaisanen T., Vaisanen M.R., Hamad O., Wang J., Bjerkvig R., Nilsson B., Pihlajaniemi T., Akerud H., Pietras K., Jahnen-Dechent W., Siegbahn A., Olsson A.K. Mol. Cancer Res.7:1792-1802(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION 9. "Genetic deficiency in plasma protein HRG enhances tumor growth and metastasis by exacerbating immune escape and vessel abnormalization." Tugues S., Honjo S., Konig C., Noguer O., Hedlund M., Botling J., Deschoemaeker S., Wenes M., Rolny C., Jahnen-Dechent W., Mazzone M., Claesson-Welsh L. Cancer Res.72:1953-1963(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE 10. "Enhanced platelet activation mediates the accelerated angiogenic switch in mice lacking histidine-rich glycoprotein." Ringvall M., Thulin A., Zhang L., Cedervall J., Tsuchida-Straeten N., Jahnen-Dechent W., Siegbahn A., Olsson A.K. PLoS ONE6:E14526-E14526(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE

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