JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Glycogen synthase kinase-3 alpha

SKU : BHE13804265

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E0767m
Alternative Names	Serine/threonine-protein kinase GSK3A ; 2.7.11.1
Categories	Elisa
Function	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transctiption factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.
Specificity	Natural and recombinant Mouse Glycogen synthase kinase-3 alpha
Detection Range	0.312-20ng/mL
Entryname	GSK3A_MOUSE
Method Type	Sandwich
Platform	PF00069
Protein Name	Glycogen synthase kinase-3 alpha
Sensitivity	0.16ng/mL
Sequence	50: MSGGGPSGGG ; PGGSGRARTS ; SFAEPGGGGG ; GGGGGPGGSA ; SGPGGTGGGK ; 100: ASVGAMGGGV ; GASSSGGGPS ; GSGGGGSGGP ; GAGTSFPPPG ; VKLGRDSGKV ; 150: TTVVATVGQG ; PERSQEVAYT ; DIKVIGNGSF ; GVVYQARLAE ; TRELVAIKKV ; 200: LQDKRFKNRE ; LQIMRKLDHC ; NIVRLRYFFY ; SSGEKKDELY ; LNLVLEYVPE ; 250: TVYRVARHFT ; KAKLITPIIY ; IKVYMYQLFR ; SLAYIHSQGV ; CHRDIKPQNL ; 300: LVDPDTAVLK ; LCDFGSAKQL ; VRGEPNVSYI ; CSRYYRAPEL ; IFGATDYTSS ; 350: IDVWSAGCVL ; AELLLGQPIF ; PGDSGVDQLV ; EIIKVLGTPT ; REQIREMNPN ; 400: YTEFKFPQIK ; AHPWTKVFKS ; SKTPPEAIAL ; CSSLLEYTPS ; SRLSPLEACA ; 450: HSFFDELRRL ; GAQLPNDRPL ; PPLFNFSPGE ; LSIQPSLNAI ; LIPPHLRSPA ; 490: GPASPLTTSY ; NPSSQALTEA ; QTGQDWQPSD ; ATTATLASSS ;
Sequence Length	490
String	Q2NL51
Sub Unit	Monomer. Interacts with AXIN1 and CTNNB1/beta-catenin (By similarity). Interacts with ARRB2.

Uniprot	Q2NL51
Gene Name	Gsk3a
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:606496
Unigene	Mm.491101

Reference	1. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 227-490 tissue: Eye. 3. "An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior." Beaulieu J.-M., Sotnikova T.D., Marion S., Lefkowitz R.J., Gainetdinov R.R., Caron M.G. Cell122:261-273(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2 4. "Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis." McManus E.J., Sakamoto K., Armit L.J., Ronaldson L., Shpiro N., Marquez R., Alessi D.R. EMBO J.24:1571-1583(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF SER-21;PHOSPHORYLATION AT SER-21 5. "Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1." Maurer U., Charvet C., Wagman A.S., Dejardin E., Green D.R. Mol. Cell21:749-760(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MCL1 PHOSPHORYLATION 6. "GSK3 alpha and GSK3 beta are necessary for axon formation." Garrido J.J., Simon D., Varea O., Wandosell F. FEBS Lett.581:1579-1586(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AXON FORMATION;TISSUE SPECIFICITY 7. "Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism." MacAulay K., Doble B.W., Patel S., Hansotia T., Sinclair E.M., Drucker D.J., Nagy A., Woodgett J.R. Cell Metab.6:329-337(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HEPATIC GLYCOGEN METABOLISM;DISRUPTION PHENOTYPE

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13804265	E0767m	96T	$776		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.