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ELISA Kit for Mouse Geminin

SKU : BHE13804660

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15220m
Categories	Elisa
Function	Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
Specificity	Natural and recombinant Mouse Geminin
Subcellular Location	Cytoplasm Nucleus Mainly cytoplasmic but can be relocalized to the nucleus.
Entryname	GEMI_MOUSE
Platform	PF07412
Protein Name	Geminin
Sequence	50: MNLSMKQKQE ; GAQENVKNSP ; VPRRTLKMIQ ; PSADGSLVGR ; ENELPKGLFK ; 100: RKLWDDQLAS ; QTSSCGPEAN ; ENKDVGDLTQ ; EAFDLISKEN ; PSSQYWKEVA ; 150: EQRRKALYEA ; LKENEKLHKE ; IEQKDSEIAR ; LRKENKDLAE ; VAEHVQYMAE ; 200: VIERLSNEPL ; DNFESPDSQE ; FDSEEEAVEY ; SELEDSGAGT ; CAEETVSSST ; 206: DARPCT
Sequence Length	206
String	O88513
Sub Unit	Homotetramer (By similarity). Interacts with IDAS; targets GMNN to the nucleus, prevents GMNN interaction with CDT1 and competes with IDAS homodimerization (By similarity). Interacts with CDT1; inhibits binding of the MCM complex to origins of replication.

Uniprot	O88513
Gene Name	Gmnn
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:57441
Unigene	Mm.12239

Reference	1. "Geminin, an inhibitor of DNA replication, is degraded during mitosis." McGarry T.J., Kirschner M.W. Cell93:1043-1053(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;DEVELOPMENTAL STAGE 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 3. "Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity." Yanagi K., Mizuno T., You Z., Hanaoka F. J. Biol. Chem.277:40871-40880(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CDT1 4. "Structural basis for inhibition of the replication licensing factor Cdt1 by geminin." Lee C., Hong B., Choi J.M., Kim Y., Watanabe S., Ishimi Y., Enomoto T., Tada S., Kim Y., Cho Y. Nature430:913-917(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 79-157 IN COMPLEX WITH CDT1;DOMAIN COILED COIL;SUBUNIT

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804660	E15220m	96T	$776		Add to Cart

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