Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Specificity
Natural and recombinant Mouse Gamma-secretase subunit APH-1A
Subcellular Location
Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus cis-Golgi network membrane Multi-pass membrane protein Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist.