Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
Specificity
Natural and recombinant Mouse Furin
Subcellular Location
Golgi apparatus trans-Golgi network membrane Single-pass type I membrane protein Cell membrane Single-pass type I membrane protein Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.
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