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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Forkhead box protein O3

SKU : BHE13812137

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0762m
Alternative Names	Fkhr2 ; Foxo3a
Categories	Elisa
Function	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Specificity	Natural and recombinant Mouse Forkhead box protein O3
Subcellular Location	Cytoplasm Cytosol Nucleus Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
Detection Range	31.2-2000pg/mL
Entryname	FOXO3_MOUSE
Method Type	Sandwich
Platform	PF00250
Protein Name	Forkhead box protein O3
Sensitivity	15.6pg/mL
Sequence	50: MAEAPASPVP ; LSPLEVELDP ; EFEPQSRPRS ; CTWPLQRPEL ; QASPAKPSGE ; 100: TAADSMIPEE ; DDDEDDEDGG ; GRASSAMVIG ; GGVSSTLGSG ; LLLEDSAMLL ; 150: APGGQDLGSG ; PASAAGALSG ; GTPTQLQPQQ ; PLPQPQPGAA ; GGSGQPRKCS ; 200: SRRNAWGNLS ; YADLITRAIE ; SSPDKRLTLS ; QIYEWMVRCV ; PYFKDKGDSN ; 250: SSAGWKNSIR ; HNLSLHSRFM ; RVQNEGTGKS ; SWWIINPDGG ; KSGKAPRRRA ; 300: VSMDNSNKYT ; KSRGRAAKKK ; AALQAAPESA ; DDSPSQLSKW ; PGSPTSRSSD ; 350: ELDAWTDFRS ; RTNSNASTVS ; GRLSPILAST ; ELDDVQDDDG ; PLSPMLYSSS ; 400: ASLSPSVSKP ; CTVELPRLTD ; MAGTMNLNDG ; LAENLMDDLL ; DNIALPPSQP ; 450: SPPGGLMQRG ; SSFPYTAKSS ; GLGSPTGSFN ; STVFGPSSLN ; SLRQSPMQTI ; 500: QENRPATFSS ; VSHYGNQTLQ ; DLLASDSLSH ; SDVMMTQSDP ; LMSQASTAVS ; 550: AQNARRNVML ; RNDPMMSFAA ; QPTQGSLVNQ ; NLLHHQHQTQ ; GALGGSRALS ; 600: NSVSNMGLSD ; SSSLGSAKHQ ; QQSPASQSMQ ; TLSDSLSGSS ; LYSASANLPV ; 650: MGHDKFPSDL ; DLDMFNGSLE ; CDMESIIRSE ; LMDADGLDFN ; FDSLISTQNV ; 672: VGLNVGNFTG ; AKQASSQSWV ; PG
Sequence Length	672
Sub Unit	Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1 (By similarity). Interacts with DDIT3/CHOP.

Uniprot	Q9WVH4
Gene Name	Foxo3
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:56484
Unigene	Mm.338613

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SKU	Supplier No.	Size	Your price	Quantity
BHE13812137	E0762m	96T	$776		Add to Cart

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