ABP-280-like protein ; ABP-L ; Actin-binding-like protein ; Filamin-2 ; Gamma-filamin ; Abpl ; Fln2
Categories
Elisa
Function
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
Specificity
Natural and recombinant Mouse Filamin-C
Subcellular Location
Cytoplasm Membrane Peripheral membrane protein Cytoplasm cytoskeleton Cytoplasm myofibril sarcomere Z line A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme.
Homodimer (By similarity). Interacts with FLNB, KCND2, INPPL1, ITGB1A, MYOT, MYOZ1 and MYOZ3. Interacts with sarcoglycans SGCD and SGCG. Interacts (via filament repeats 17-18, 20-21 and 24) with USP25 (isoform USP25m only) (By similarity). Interacts with KY. Interacts with IGFN1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1687-1800 (ISOFORMS 1 AND 2);DEVELOPMENTAL STAGE
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2234;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]