Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
Specificity
Natural and recombinant Mouse Fatty-acid amide hydrolase 1
Subcellular Location
Endoplasmic reticulum membrane Single-pass membrane protein Golgi apparatus membrane Single-pass membrane protein Seems to be associated with the endoplasmic reticulum and/or Golgi apparatus.