Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
Specificity
Natural and recombinant Mouse EGF-containing fibulin-like extracellular matrix protein 1
Subcellular Location
Secreted extracellular space Secreted extracellular space extracellular matrix Localizes to the lamina propria underneath the olfactory epithelium.