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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Disks large homolog 4

SKU : BHE13803356

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12411m
Alternative Names	Postsynaptic density protein 95 ; PSD-95 ; Synapse-associated protein 90 ; SAP-90 ; Dlgh4 ; Psd95
Categories	Elisa
Function	Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
Specificity	Natural and recombinant Mouse Disks large homolog 4
Subcellular Location	Cell membrane Peripheral membrane protein Cell junction synapse postsynaptic cell membrane postsynaptic density Cell junction synapse Cell junction synapse synaptosome Membrane-associated. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
Detection Range	0.156-10ng/mL
Entryname	DLG4_MOUSE
Method Type	Sandwich
Platform	PF00625
Protein Name	Disks large homolog 4
Sensitivity	0.088ng/mL
Sequence	50: MDCLCIVTTK ; KYRYQDEDTP ; PLEHSPAHLP ; NQANSPPVIV ; NTDTLEAPGY ; 100: ELQVNGTEGE ; MEYEEITLER ; GNSGLGFSIA ; GGTDNPHIGD ; DPSIFITKII ; 150: PGGAAAQDGR ; LRVNDSILFV ; NEVDVREVTH ; SAAVEALKEA ; GSIVRLYVMR ; 200: RKPPAEKIIE ; IKLIKGPKGL ; GFSIAGGVGN ; QHIPGDNSIY ; VTKIIEGGAA ; 250: HKDGRLQIGD ; KILAVNSVGL ; EDVMHEDAVA ; ALKNTYDVVY ; LKVAKPSNAY ; 300: LSDSYAPPDI ; TTSYSQHLDN ; EISHSSYLGT ; DYPTAMTPTS ; PRRYSPVAKD ; 350: LLGEEDIPRE ; PRRIVIHRGS ; TGLGFNIVGG ; EDGEGIFISF ; ILAGGPADLS ; 400: GELRKGDQIL ; SVNGVDLRNA ; SHEQAAIALK ; NAGQTVTIIA ; QYKPEEYSRF ; 450: EAKIHDLREQ ; LMNSSLGSGT ; ASLRSNPKRG ; FYIRALFDYD ; KTKDCGFLSQ ; 500: ALSFHFGDVL ; HVIDASDEEW ; WQARRVHSDS ; ETDDIGFIPS ; KRRVERREWS ; 550: RLKAKDWGSS ; SGSQGREDSV ; LSYETVTQME ; VHYARPIIIL ; GPTKDRANDD ; 600: LLSEFPDKFG ; SCVPHTTRPK ; REYEIDGRDY ; HFVSSREKME ; KDIQAHKFIE ; 650: AGQYNSHLYG ; TSVQSVREVA ; EQGKHCILDV ; SANAVRRLQA ; AHLHPIAIFI ; 700: RPRSLENVLE ; INKRITEEQA ; RKAFDRATKL ; EQEFTECFSA ; IVEGDSFEEI ; 724: YHKVKRVIED ; LSGPYIWVPA ; RERL
Sequence Length	724
String	Q62108
Sub Unit	Interacts through its PDZ domains with NETO1. Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ACCN3, certain splice forms of GRIN1, KCND2, CXADR, SYNGAP1, KCNA1, KCNA2, KCNA3, KCNA4 and ERBB4. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. Interacts through its third PDZ domain with NLGN1 and CRIPT, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A, BEGAIN and KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK. Interacts with ANKS1B and PRR7 (By similarity). Interacts with ADR1B. May interact with HTR2A. Interacts with ADAM22, KLHL17 and LGI1 (By similarity). Interacts with ANO2 through its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts (via guanylate kinase-like domain) with SIPA1L1 (By similarity). Interacts (via PDZ1 and PDZ2 domains) with LRRC4; LRRC4B and SEMA4C. Interacts with LRFN1, LRFN2 and LRFN4, but not with LRFN3 nor LRFN5.

Uniprot	Q62108
Gene Name	Dlg4
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:13385
Unigene	Mm.27256

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803356	E12411m	96T	$776		Add to Cart

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