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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Disintegrin and metalloproteinase domain-containing protein 12

SKU : BHE13800584

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14640m
Alternative Names	Meltrin-alpha ; Mltna
Categories	Elisa
Function	Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.
Specificity	Natural and recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 12
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	0.78-50ng/mL
Entryname	ADA12_MOUSE
Method Type	Sandwich
Platform	PF08516
Protein Name	Disintegrin and metalloproteinase domain-containing protein 12
Sensitivity	0.46ng/mL
Sequence	50: MAERPARRAP ; PARALLLALA ; GALLAPRAAR ; GMSLWDQRGA ; YEVARASLLS ; 100: KDPGIPGQSI ; PAKDHPDVLT ; VQLQLESRDL ; ILSLERNEGL ; IANGFTETHY ; 150: LQDGTDVSLT ; RNHTDHCYYH ; GHVQGDAASV ; VSLSTCSDLR ; GLIMFENKTY ; 200: SLEPMKNTTD ; SYKLVPAESM ; TNIQGLCGSQ ; HNKSNLTMED ; VSPGTSQMRA ; 250: RRHKRETLKM ; TKYVELVIVA ; DNREFQRQGK ; DLEKVKQRLI ; EIANHVDKFY ; 300: RPLNIRIVLV ; GVEVWNDIDK ; CSISQDPFTR ; LHEFLDWRKI ; KLLPRKSHDN ; 350: AQLISGVYFQ ; GTTIGMAPIM ; SMCTAEQSGG ; VVMDHSDSPL ; GAAVTLAHEL ; 400: GHNFGMNHDT ; LERGCSCRMA ; AEKGGCIMNP ; STGFPFPMVF ; SSCSRKDLEA ; 450: SLEKGMGMCL ; FNLPEVKQAF ; GGRKCGNGYV ; EEGEECDCGE ; PEECTNRCCN ; 500: ATTCTLKPDA ; VCAHGQCCED ; CQLKPPGTAC ; RGSSNSCDLP ; EFCTGTAPHC ; 550: PANVYLHDGH ; PCQGVDGYCY ; NGICQTHEQQ ; CVTLWGPGAK ; PAPGICFERV ; 600: NSAGDPYGNC ; GKDSKSAFAK ; CELRDAKCGK ; IQCQGGASRP ; VIGTNAVSIE ; 650: TNIPQQEGGR ; ILCRGTHVYL ; GDDMPDPGLV ; LAGTKCAEGK ; ICLNRRCQNI ; 700: SVFGVHKCAM ; QCHGRGVCNN ; RKNCHCEAHW ; APPFCDKFGF ; GGSTDSGPIR ; 750: QADNQGLTVG ; ILVSILCLLA ; AGFVVYLKRK ; TLMRLLFTHK ; KTTMEKLRCV ; 800: HPSRTPSGPH ; LGQAHHTPGK ; GLLMNRAPHF ; NTPKDRHSLK ; CQNMDISRPL ; 850: DARAVPQLQS ; PQRVLLPLHQ ; TPRAPSGPAR ; PLPASPAVRQ ; AQGIRKPSPP ; 900: QKPLPADPLS ; RTSRLTSALV ; RTPGQQEPGH ; RPAPIRPAPK ; HQVPRPSHNA ; 903: YIK
Sequence Length	903
String	Q61824
Sub Unit	Interacts with alpha-actinin-2 and with syndecans. Interacts with SH3PXD2A. Interacts with FST3. Interacts with GNB2L1/RACK1; the interaction is required for PKC-dependent translocation of ADAM12 to the cell membrane.

Uniprot	Q61824
Gene Name	Adam12
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:11489
Unigene	Mm.439714

Reference	1. "A metalloprotease-disintegrin participating in myoblast fusion." Yagami-Hiromasa T., Sato T., Kurisaki T., Kamijo K., Nabeshima Y., Fujisawa-Sehara A. Nature377:652-656(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Embryonic fibroblast. 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. "Spatially- and temporally-restricted expression of meltrin alpha (ADAM12) and beta (ADAM19) in mouse embryo." Kurisaki T., Masuda A., Osumi N., Nabeshima Y., Fujisawa-Sehara A. Mech. Dev.73:211-215(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY 4. "Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha-actinin-2, is required for myoblast fusion." Galliano M.-F., Huet C., Frygelius J., Polgren A., Wewer U.M., Engvall E. J. Biol. Chem.275:13933-13939(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ALPHA-ACTININ-2 5. "Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src." Suzuki A., Kadota N., Hara T., Nakagami Y., Izumi T., Takenawa T., Sabe H., Endo T. Oncogene19:5842-5850(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-901

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800584	E14640m	96T	$776		Add to Cart

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