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ELISA Kit for Mouse Death-associated protein kinase 3

SKU : BHE13803513

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15322m
Alternative Names	DAP-like kinase ; Dlk ; MYPT1 kinase ; ZIP-kinase ; Zipk
Categories	Elisa
Function	Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.
Specificity	Natural and recombinant Mouse Death-associated protein kinase 3
Subcellular Location	Nucleus Cytoplasm Chromosome centromere Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments. Associates to centromeres from prophase to anaphase.
Entryname	DAPK3_MOUSE
Platform	PF00069
Protein Name	Death-associated protein kinase 3
Sequence	50: MSTFRQEDVE ; DHYEMGEELG ; SGQFAIVRKC ; QQKGTGMEYA ; AKFIKKRRLP ; 100: SSRRGVSREE ; IEREVSILRE ; IRHPNIITLH ; DVFENKTDVV ; LILELVSGGE ; 150: LFDFLAEKES ; LTEDEATQFL ; KQILDGVHYL ; HSKRIAHFDL ; KPENIMLLDK ; 200: HAASPRIKLI ; DFGIAHRIEA ; GSEFKNIFGT ; PEFVAPEIVN ; YEPLGLEADM ; 250: WSIGVITYIL ; LSGASPFLGE ; TKQETLTNIS ; AVNYDFDEEY ; FSSTSELAKD ; 300: FIRRLLVKDP ; KRRMTIAQSL ; EHSWIKVRRR ; EDGARKPERR ; RLRAARLREY ; 350: SLKSHSSMPR ; NTSYASFERF ; SRVLEDVAAA ; EQGLRELQRG ; RRQCRERVCA ; 400: LRAAAEQREA ; RCRDGSAGLG ; RDLRRLRTEL ; GRTEALRTRA ; QEEARAALLG ; 448: AGGLKRRLCR ; LENRYDALAA ; QVAAEVQFVR ; DLVRALEQER ; LQAECGVR
Sequence Length	448
String	O54784
Sub Unit	Homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. Also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. Interacts with AATF and CDC5L.

Uniprot	O54784
Gene Name	Dapk3
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:13144
Unigene	Mm.10294

Reference	1. "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis." Kawai T., Matsumoto M., Takeda K., Sanjo H., Akira S. Mol. Cell. Biol.18:1642-1651(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CATALYTIC ACTIVITY;COFACTOR;FUNCTION IN APOPTOSIS;TISSUE SPECIFICITY;INTERACTION WITH ATF4;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-42; VAL-422; VAL-429 AND LEU-436 2. "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains." Kawai T., Akira S., Reed J.C. Mol. Cell. Biol.23:6174-6186(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;SUBCELLULAR LOCATION;INTERACTION WITH DAXX AND PAWR 3. "ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts." Komatsu S., Ikebe M. J. Cell Biol.165:243-254(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MYL12B;CATALYTIC ACTIVITY;FUNCTION IN CYTOSKELETON REORGANIZATION 4. "Physical and functional interactions between STAT3 and ZIP kinase." Sato N., Kawai T., Sugiyama K., Muromoto R., Imoto S., Sekine Y., Ishida M., Akira S., Matsuda T. Int. Immunol.17:1543-1552(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF STAT3;CATALYTIC ACTIVITY;INTERACTION WITH STAT3 5. "Phosphorylation of threonine-265 in zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines." Sato N., Kamada N., Muromoto R., Kawai T., Sugiyama K., Watanabe T., Imoto S., Sekine Y., Ohbayashi N., Ishida M., Akira S., Matsuda T. Immunol. Lett.103:127-134(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOPHOSPHORYLATION AT THR-265 6. "Physical and functional interactions between ZIP kinase and UbcH5." Ohbayashi N., Okada K., Kawakami S., Togi S., Sato N., Ikeda O., Kamitani S., Muromoto R., Sekine Y., Kawai T., Akira S., Matsuda T. Biochem. Biophys. Res. Commun.372:708-712(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2D1; UBE2D2 AND UBE2D3;UBIQUITINATION;SUBCELLULAR LOCATION 7. "Phosphorylation-dependent control of ZIPK nuclear import is species specific." Weitzel D.H., Chambers J., Haystead T.A. Cell. Signal.23:297-303(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF 289-ARG-ARG-290 AND ALA-294 8. "Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)." Togi S., Ikeda O., Kamitani S., Nakasuji M., Sekine Y., Muromoto R., Nanbo A., Oritani K., Kawai T., Akira S., Matsuda T. J. Biol. Chem.286:19170-19177(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NLK AND TCF7L2 9. "Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages." Arif A., Chatterjee P., Moodt R.A., Fox P.L. Mol. Cell. Biol.32:5046-5055(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RPL13A;CATALYTIC ACTIVITY

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