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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Cytoplasmic tyrosine-protein kinase BMX

SKU : BHE13801658

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2227m
Alternative Names	Bone marrow tyrosine kinase gene in chromosome X protein homolog
Categories	Elisa
Function	Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
Specificity	Natural and recombinant Mouse Cytoplasmic tyrosine-protein kinase BMX
Subcellular Location	Cytoplasm Localizes to the edges of spreading cells when complexed with BCAR1.
Detection Range	0.78-50ng/mL
Entryname	BMX_MOUSE
Method Type	Sandwich
Platform	PF00779
Protein Name	Cytoplasmic tyrosine-protein kinase BMX
Sensitivity	0.39ng/mL
Sequence	50: MESKSILEEL ; LLKKSQQKKK ; MSPNNYKERL ; FVLTKTSLSY ; YEYDKMKRGS ; 100: RKGSIEIKKI ; RCVEKVNLEE ; QTPVERQYPF ; QIVYKDGLLY ; VYASNEESRC ; 150: QWLKALQKEI ; RGNPHLLIKY ; HSGFFVDGKF ; LCCQQSCKAA ; PGCTLWEAYA ; 200: DLHIAISDEK ; HRAPTFPERL ; LKIPRAVPVL ; KMDASSSGAI ; LPQYDSYSKK ; 250: SCGSQPTSNI ; RYIPREDCPD ; WWQVRKLKSE ; EDIACSNQLE ; RNIASHSTSK ; 300: MSWGFPESSS ; SEEEENLHAY ; DWFAGNISRS ; QSEQLLRQKG ; KEGAFMVRNS ; 350: SQMGMYTVSL ; FSKAVNDKKG ; TVKHYHVHTN ; AENKLYLAEN ; YCFDSIPKLI ; 400: HYHQHNSAGM ; ITRLRHPVST ; KANKVPVSVA ; LGSGIWELKR ; EEITLLKELG ; 450: NGQFGVVQLG ; QWKGQYDVAV ; KMIKEGAMSE ; DEFFQEAQTM ; MKLSHPKLVK ; 500: FYGVCSKKYP ; IYIVTEYITN ; GCLLNYLKSH ; GKGLESCQLL ; EMCYDVCEGM ; 550: AFLESHQFIH ; RDLAARNCLV ; DSDLSVKVSD ; FGMTRYVLDD ; QYVSSVGTKF ; 600: PVKWSAPEVF ; HYFKYSSKSD ; VWAFGILMWE ; VFSLGKQPYD ; LYDNSEVVVK ; 650: VSQGHRLYRP ; QLASDTIYQI ; MYSCWHELPE ; KRPTFQQLLS ; AIEPLREQDK ; 651: P
Sequence Length	651
String	P97504
Sub Unit	Interacts with BCAR1, CAV1, MYD88, PTK2, RUFY1, RUFY2, STAT3, TIRAP and TNFRSF1B.

Uniprot	P97504
Gene Name	Bmx
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:12169
Unigene	Mm.504

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801658	E2227m	96T	$776		Add to Cart

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