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ELISA Kit for Mouse Coronin-1A

SKU : BHE13803066

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0023m
Alternative Names	Coronin-like protein A ; Clipin-A ; Coronin-like protein p57 ; Tryptophan aspartate-containing coat protein ; TACO ; Coro1
Categories	Elisa
Function	May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Specificity	Natural and recombinant Mouse Coronin-1A
Subcellular Location	Cytoplasm cytoskeleton Cytoplasm cell cortex Cytoplasmic vesicle phagosome membrane In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.
Detection Range	0.156-10ng/mL
Entryname	COR1A_MOUSE
Method Type	Sandwich
Platform	PF08953
Protein Name	Coronin-1A
Sensitivity	0.086ng/mL
Sequence	50: MSRQVVRSSK ; FRHVFGQPAK ; ADQCYEDVRV ; SQTTWDSGFC ; AVNPKFMALI ; 100: CEASGGGAFL ; VLPLGKTGRV ; DKNVPLVCGH ; TAPVLDIAWC ; PHNDNVIASG ; 150: SEDCTVMVWE ; IPDGGLVLPL ; REPVITLEGH ; TKRVGIVAWH ; PTAQNVLLSA ; 200: GCDNVILVWD ; VGTGAAVLTL ; GPDVHPDTIY ; SVDWSRDGAL ; ICTSCRDKRV ; 250: RVIEPRKGTV ; VAEKDRPHEG ; TRPVHAVFVS ; EGKILTTGFS ; RMSERQVALW ; 300: DTKHLEEPLS ; LQELDTSSGV ; LLPFFDPDTN ; IVYLCGKGDS ; SIRYFEITSE ; 350: APFLHYLSMF ; SSKESQRGMG ; YMPKRGLEVN ; KCEIARFYKL ; HERKCEPIAM ; 400: TVPRKSDLFQ ; EDLYPPTAGP ; DPALTAEEWL ; GGRDAGPLLI ; SLKDGYVPPK ; 450: SRELRVNRGL ; DSARRRATPE ; PSGTPSSDTV ; SRLEEDVRNL ; NAIVQKLQER ; 461: LDRLEETVQA ; K
Sequence Length	461
String	O89053
Sub Unit	Binds actin.

Uniprot	O89053
Gene Name	Coro1a
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:12721
Unigene	Mm.290482

Reference	1. "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein." Okumura M., Kung C., Wong S., Rodgers M., Thomas M.L. DNA Cell Biol.17:779-787(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "A coat protein on phagosomes involved in the intracellular survival of mycobacteria." Ferrari G., Langen H., Naito M., Pieters J. Cell97:435-447(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 11-14;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;ROLE IN PHAGOSOME TRAFFICKING strain: C57BL/6. tissue: Macrophage. 3. "A new therapeutic strategy of mycobacterium infection by use of anti-TACO sequence." Kohchi C., Inagawa H., Makino K., Terada H., Soma G. Submitted (2002-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Hematopoietic. tissue: Mammary tumor. 5. "Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis." Chu C.C., Paul W.E. Mol. Immunol.35:487-502(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 156-276 strain: BALB/c. tissue: Spleen. 6. Lubec G., Klug S. Submitted (2007-03) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 215-233;IDENTIFICATION BY MASS SPECTROMETRY tissue: Hippocampus. 7. "The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-418;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 8. "Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin." Oku T., Nakano M., Kaneko Y., Ando Y., Kenmotsu H., Itoh S., Tsuiji M., Seyama Y., Toyoshima S., Tsuji T. J. Biol. Chem.287:42910-42920(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-412 9. "A conserved trimerization motif controls the topology of short coiled coils." Kammerer R.A., Kostrewa D., Progias P., Honnappa S., Avila D., Lustig A., Winkler F.K., Pieters J., Steinmetz M.O. Proc. Natl. Acad. Sci. U.S.A.102:13891-13896(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 430-461;COILED-COIL DOMAIN 10. "The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes." Appleton B.A., Wu P., Wiesmann C. Structure14:87-96(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 1-402;WD REPEATS;COILED-COIL DOMAIN

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