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ELISA Kit for Mouse Chromodomain-helicase-DNA-binding protein 8

SKU : BHE13803049

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11393m
Alternative Names	ATP-dependent helicase CHD8 ; Axis duplication inhibitor ; Duplin ; Kiaa1564
Categories	Elisa
Function	DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating to efficient U6 RNA polymerase III transcription.
Specificity	Natural and recombinant Mouse Chromodomain-helicase-DNA-binding protein 8
Subcellular Location	Nucleus Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites.
Entryname	CHD8_MOUSE
Platform	PF07533
Protein Name	Chromodomain-helicase-DNA-binding protein 8
Sequence	50: MADPIMDLFD ; DPNLFGLDSL ; TDDSFNQVTQ ; DPIEEALGLP ; SSLDSLDQMN ; 100: QDGGGGDVGN ; SSASDLVPPP ; EETASTELPK ; ESTAPAPESL ; TLHDYTTQPT ; 150: SQEQPAQPVL ; QTSTPTAGLL ; QVSKSQEILS ; QGNPFMGVSA ; TGVSPSNTGG ; 200: QPSQSAPKIV ; ILKAPPNSSV ; TGTHVAQIQA ; QGITSTAQPL ; VAGTANGGKV ; 250: TFTKVLTGTP ; LRPGVSIVSG ; NTVLATKVPG ; NQAAVQRIVQ ; PSRPVKQLVL ; 300: QPVKGSAPAG ; NPGAAGPPLK ; PAVTLTSTPT ; QGESKRITLV ; LQQPQSGGPQ ; 350: GHRHVVLGSL ; PGKIVLQGNQ ; LAALTQAKNA ; QGQPAKVVTI ; QLQVQQPQQK ; 400: IQIVPQPPSS ; QPQPQPQPPP ; SAQPLTLSSV ; QQAQIMGPGQ ; NPGQRLSVPL ; 450: KMVLQPQAGS ; SQGASSGLSV ; VKVLSASEVA ; ALSSPASCAP ; HTAGKTGMEE ; 500: NRRLEHQKKQ ; EKANRIVAEA ; IARARARGEQ ; NIPRVLNEDE ; LPSVRPEEEG ; 550: EKKRRKKSSG ; ERLKEEKPKK ; SKTAAASKTK ; GKSKLNTITP ; VVGKKRKRNT ; 600: SSDNSDVEVM ; PAQSPREDEE ; SSIQKRRSNR ; QVKRKKYTED ; LDIKITDDEE ; 650: EEEVDVTGPI ; KPEPILPEPV ; QEPDGETLPS ; MQFFVENPSE ; EDAAIVDKVL ; 700: SMRVVKKELP ; SGQYTEAEEF ; FVKYKNYSYL ; HCEWATISQL ; EKDKRIHQKL ; 750: KRFKTKMAQM ; RHFFHEDEEP ; FNPDYVEVDR ; ILDESHSVDK ; DNGEPVIYYL ; 800: VKWCSLPYED ; STWELKEDVD ; EGKIREFKRI ; QSRHPELRRV ; NRPQANAWKK ; 850: LELSHEYKNR ; NQLREYQLEG ; VNWLLFNWYN ; RQNCILADEM ; GLGKTIQSIA ; 900: FLQEVYNVGI ; HGPFLVIAPL ; STITNWEREF ; NTWTEMNTIV ; YHGSLASRQM ; 950: IQQYEMYCKD ; SRGRLIPGAY ; KFDALITTFE ; MILSDCPELR ; EIEWRCVIID ; 1000: EAHRLKNRNC ; KLLDSLKHMD ; LEHKVLLTGT ; PLQNTVEELF ; SLLHFLEPSQ ; 1050: FPSESEFLKD ; FGDLKTEEQV ; QKLQAILKPM ; MLRRLKEDVE ; KNLAPKQETI ; 1100: IEVELTNIQK ; KYYRAILEKN ; FSFLSKGAGH ; TNMPNLLNTM ; MELRKCCNHP ; 1150: YLINGAEEKI ; LMEFREACHI ; IPQDFHLQAM ; VRSAGKLVLI ; DKLLPKLKAG ; 1200: GHKVLIFSQM ; VRCLDILEDY ; LIQRRYLYER ; IDGRVRGNLR ; QAAIDRFSKP ; 1250: DSDRFVFLLC ; TRAGGLGINL ; TAADTCIIFD ; SDWNPQNDLQ ; AQARCHRIGQ ; 1300: SKAVKVYRLI ; TRNSYEREMF ; DKASLKLGLD ; KAVLQSMSGR ; DGNITGIQQF ; 1350: SKKEIEDLLR ; KGAYAAIMEE ; DDEGSKFCEE ; DIDQILLRRT ; TTITIESEGK ; 1400: GSTFAKASFV ; ASENRTDISL ; DDPNFWQKWA ; KKADLDMDLL ; NSKNNLVIDT ; 1450: PRVRKQTRHF ; STLKDDDLVE ; FSDLESEDDE ; RPRSRRHDRH ; HTYGRTDCFR ; 1500: VEKHLLVYGW ; GRWRDILSHG ; RFKRRMTERD ; VETICRAILV ; YCLLHYRGDE ; 1550: NIKSFIWDLI ; SPAENGKTKE ; LQNHSGLSIP ; VPRGRKGKKV ; KSQSTFDIHK ; 1600: ADWIRKYNPD ; TLFQDESYKK ; HLKHQCNKVL ; LRVRMLYYLR ; QEVIGDQAEK ; 1650: VLGGAIASEI ; DIWFPVVDQL ; EVPTTWWDSE ; ADKSLLIGVF ; KHGYEKYNTM ; 1700: RADPALCFLE ; KAGRPDDKAI ; AAEHRVLDNF ; SDLVEGIDFD ; KDCEDPEYKP ; 1750: LQGPPKDPDD ; EGDPLMMMDE ; EISVIDGEEA ; QVTQQPGHLF ; WPPGSALTAR ; 1800: LRRLVTAYQR ; SYKREQMKME ; AAERGDRRRR ; RCEAAFKLKE ; IARREKQQRW ; 1850: TRREQTDFYR ; VVSTFGVEYD ; PDNMQFHWDR ; FRTFARLDKK ; TDESLTKYFH ; 1900: GFVAMCRQVC ; RLPPAAGDEP ; PDPNLFIEPI ; TEERASRTLY ; RIELLRRLRE ; 1950: QVLCHPLLED ; RLALCQPPGL ; ELPKWWEPVR ; HDGELLRGAA ; RHGVSQTDCN ; 2000: IMQDPDFSFL ; AARMNYMQNH ; QAGASAASLS ; RCSTPLLHQQ ; CTSRTASPSP ; 2050: LRPDAPVEKS ; PEESTVQVPN ; LESLTLKLED ; EVVARSRLTS ; QDYEVRVGSS ; 2100: DTAPLSRSVP ; PVKLEDEDDS ; DSELDLSKLS ; PSSSSSSSSS ; SSSSSTDESE ; 2150: DEKEEKLTAD ; RSRPKLYDEE ; SLLSLTMSQD ; GFPNEDGEQM ; TPELLLLQER ; 2200: QRASEWPKDR ; VLINRIDLVC ; QAVLSGKWPS ; NRRSQEVTAG ; GILGPGNHLL ; 2250: DSPSLTPGED ; GDSPVPTPRS ; GSAASMAEEE ; ASAVTTAAAQ ; FTKLRRGMDE ; 2300: KEFTVQIKDE ; EGLKLTFQKH ; RLMANGVMGD ; GHPLFHKKKG ; NRKKLVELEV ; 2350: ECMEEPNHLD ; LDLETRIPVI ; NKVDGTLLVG ; DEAPRRAELE ; MWLQGHPEFA ; 2400: VDPRFLAYME ; ERRKQKWQRC ; KKNNKAELNC ; LGMEPVQPAN ; SRNGKKGHYA ; 2450: ETAFNRVLPG ; PVAPENSKKR ; VRRTRPDLSK ; MMALMQGGST ; GSLSLHNTFQ ; 2500: HSSSNLQSVS ; SLGHSSTTSA ; SLPFMPFVMG ; AAAPPHVDSS ; TMLHHHHHHP ; 2550: HPHHHHHHHP ; GLRTTGYPSS ; PATTTSGTAL ; RLPTLQPEDD ; DEEEDEEDDD ; 2582: LSQGYDSSER ; DFSLIDDPMM ; PANSDSSEDA ; DD
Sequence Length	2582
String	Q09XV5
Sub Unit	Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of a multiprotein complex of 900 kDa containing WDR5.

Uniprot	Q09XV5
Gene Name	Chd8
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:67772
Unigene	Mm.289934

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BHE13803049	E11393m	96T	$776		Add to Cart

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