Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.
Specificity
Natural and recombinant Mouse Cholesterol 25-hydroxylase
Subcellular Location
Endoplasmic reticulum membrane Multi-pass membrane protein