JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Cellular tumor antigen p53

SKU : BHE13808188

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E0928m
Alternative Names	Tumor suppressor p53 ; P53 ; Trp53
Categories	Elisa
Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.
Specificity	Natural and recombinant Mouse Cellular tumor antigen p53
Subcellular Location	Cytoplasm Nucleus Endoplasmic reticulum Nucleus PML body Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2.
Detection Range	15.6-1000pg/mL
Entryname	P53_MOUSE
Method Type	Sandwich
Platform	PF00870
Protein Name	Cellular tumor antigen p53
Sensitivity	8.04pg/mL
Sequence	50: MEESQSDISL ; ELPLSQETFS ; GLWKLLPPED ; ILPSPHCMDD ; LLLPQDVEEF ; 100: FEGPSEALRV ; SGAPAAQDPV ; TETPGPVAPA ; PATPWPLSSF ; VPSQKTYQGN ; 150: YGFHLGFLQS ; GTAKSVMCTY ; SPPLNKLFCQ ; LAKTCPVQLW ; VSATPPAGSR ; 200: VRAMAIYKKS ; QHMTEVVRRC ; PHHERCSDGD ; GLAPPQHLIR ; VEGNLYPEYL ; 250: EDRQTFRHSV ; VVPYEPPEAG ; SEYTTIHYKY ; MCNSSCMGGM ; NRRPILTIIT ; 300: LEDSSGNLLG ; RDSFEVRVCA ; CPGRDRRTEE ; ENFRKKEVLC ; PELPPGSAKR ; 350: ALPTCTSASP ; PQKKKPLDGE ; YFTLKIRGRK ; RFEMFRELNE ; ALELKDAHAT ; 387: EESGDSRAHS ; SYLKTKKGQS ; TSRHKKTMVK ; KVGPDSD
Sequence Length	387
String	P02340
Sub Unit	Binds DNA as a homotetramer. Found in a complex with CABLES1 and TP73. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. The C-terminus interacts with TAF1, when TAF1 is part of the TFIID complex. Interacts with HIPK1, HIPK2, AXIN1, and P53DINP1. Part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction (By similarity). Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquination and degradation of TP53. Interacts with DAXX. Interacts (when monomethylated at Lys-376) with L3MBTL1 (By similarity). Interacts with BANP, CDKN2AIP, NUAK1, STK11/LKB1 and E4F1. Interacts with CHD8, leading to recruit histone H1 and prevent transactivation activity. Interacts with AURKA, TRIM24 and BRD7. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Phosphorylated at Ser-309 and Ser-386 by CDK2 in response to DNA-damage.

Uniprot	P02340
Gene Name	Tp53
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:22059
Unigene	Mm.222

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13808188	E0928m	96T	$776		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.