JNK-associated leucine-zipper protein ; JLP ; JNK/SAPK-associated protein 2 ; JSAP2 ; Mitogen-activated protein kinase 8-interacting protein 4 ; Sperm-associated antigen 9 ; Jip4 ; Jsap2 ; Kiaa0516 ; Mapk8ip4
Categories
Elisa
Function
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module.
Specificity
Natural and recombinant Mouse C-Jun-amino-terminal kinase-interacting protein 4
Subcellular Location
Cytoplasm Cytoplasm perinuclear region Perinuclear distribution in response to stress signals such as UV radiation.
Homooligomer. Interacts with MAX, MAPK8, MAPK14, MAPK10, MAPK14, MAP3K3, MYC, KNS2, and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8.