ELISA Kit for Mouse Breast cancer metastasis-suppressor 1 homolog

Mfr.No.	E9631m
Categories	Elisa
Function	Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis.
Specificity	Natural and recombinant Mouse Breast cancer metastasis-suppressor 1 homolog
Subcellular Location	Nucleus Cytoplasm Predominantly nuclear.
Detection Range	0.156-10ng/mL
Entryname	BRMS1_MOUSE
Method Type	Sandwich
Platform	PF08598
Protein Name	Breast cancer metastasis-suppressor 1 homolog
Sensitivity	0.087ng/mL
Sequence	50: MPIQPSGKET ; EEMEAEGDSA ; AEMNGEADES ; EEERSGSQTE ; SEEESSEMDD ; 100: EDYERRRSEC ; VSEMLDLEKQ ; FSELKEKLFR ; ERLSQLRLRL ; EEVGAERAPE ; 150: YTEPLGGLQQ ; SLKIRIQVAG ; IYKGFCLDVI ; RNKYECELQG ; AKQHLESEKM ; 200: LLYDTLLGEL ; QERIQRLEED ; RQSLDISSEW ; WDDKLHSRSS ; SKAGDAMPPS ; 246: KRKKAPLVSG ; PYIVYMLQEI ; DILEDWTAIK ; KARAAVSPQK ; RKADGP
Sequence Length	246
Sub Unit	Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2.

Reference	1. "Brms1: murine homolog of human breast metastasis suppressor gene-1 (BRMS1)." Samant R.S., Debies M.T., Welch D.R. Submitted (2000-02) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: BALB/c. 2. "Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1)." Samant R.S., Debies M.T., Shevde L.A., Verderame M.F., Welch D.R. Int. J. Cancer97:15-20(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] strain: 129/Sv. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: FVB/N. tissue: Salivary gland.

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BHE13801782	E9631m	96T	$776		Add to Cart