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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Beta-secretase 1

SKU : BHE13801713

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0718m
Alternative Names	Aspartyl protease 2 ; ASP2 ; Beta-site amyloid precursor protein cleaving enzyme 1 ; Beta-site APP cleaving enzyme 1 ; Memapsin-2 ; Membrane-associated aspartic protease 2 ; Bace
Categories	Elisa
Function	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Specificity	Natural and recombinant Mouse Beta-secretase 1
Subcellular Location	Membrane Single-pass type I membrane protein Golgi apparatus trans-Golgi network Endoplasmic reticulum Endosome Cell surface Cytoplasmic vesicle membrane Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
Detection Range	0.78-50ng/mL
Entryname	BACE1_MOUSE
Method Type	Sandwich
Platform	PF00026
Protein Name	Beta-secretase 1
Sensitivity	0.39ng/mL
Sequence	50: MAPALHWLLL ; WVGSGMLPAQ ; GTHLGIRLPL ; RSGLAGPPLG ; LRLPRETDEE ; 100: SEEPGRRGSF ; VEMVDNLRGK ; SGQGYYVEMT ; VGSPPQTLNI ; LVDTGSSNFA ; 150: VGAAPHPFLH ; RYYQRQLSST ; YRDLRKGVYV ; PYTQGKWEGE ; LGTDLVSIPH ; 200: GPNVTVRANI ; AAITESDKFF ; INGSNWEGIL ; GLAYAEIARP ; DDSLEPFFDS ; 250: LVKQTHIPNI ; FSLQLCGAGF ; PLNQTEALAS ; VGGSMIIGGI ; DHSLYTGSLW ; 300: YTPIRREWYY ; EVIIVRVEIN ; GQDLKMDCKE ; YNYDKSIVDS ; GTTNLRLPKK ; 350: VFEAAVKSIK ; AASSTEKFPD ; GFWLGEQLVC ; WQAGTTPWNI ; FPVISLYLMG ; 400: EVTNQSFRIT ; ILPQQYLRPV ; EDVATSQDDC ; YKFAVSQSST ; GTVMGAVIME ; 450: GFYVVFDRAR ; KRIGFAVSAC ; HVHDEFRTAA ; VEGPFVTADM ; EDCGYNIPQT ; 500: DESTLMTIAY ; VMAAICALFM ; LPLCLMVCQW ; RCLRCLRHQH ; DDFADDISLL ; 501: K
Sequence Length	501
String	P56818
Sub Unit	Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4. Interacts with SNX6.

Uniprot	P56818
Gene Name	Bace1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:23821
Unigene	Mm.24044

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801713	E0718m	96T	$776		Add to Cart

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