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ELISA Kit for Mouse Autoimmune regulator

SKU : BHE13801180

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13302m
Alternative Names	Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog ; APECED protein homolog
Categories	Elisa
Function	Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
Specificity	Natural and recombinant Mouse Autoimmune regulator
Subcellular Location	Nucleus Cytoplasm Predominantly nuclear but also cytoplasmic. Found in nuclear body-like structures and in a filamentous vimentin-like pattern.
Detection Range	0.625-40ng/mL
Entryname	AIRE_MOUSE
Method Type	Sandwich
Platform	PF00628
Protein Name	Autoimmune regulator
Sensitivity	0.319ng/mL
Sequence	50: MAGGDGMLRR ; LLRLHRTEIA ; VAIDSAFPLL ; HALADHDVVP ; EDKFQETLRL ; 100: KEKEGCPQAF ; HALLSWLLTR ; DSGAILDFWR ; ILFKDYNLER ; YSRLHSILDG ; 150: FPKDVDLNQS ; RKGRKPLAGP ; KAAVLPPRPP ; TKRKALEEPR ; ATPPATLASK ; 200: SVSSPGSHLK ; TKPPKKPDGN ; LESQHLPLGN ; GIQTMAASVQ ; RAVTVASGDV ; 250: PGTRGAVEGI ; LIQQVFESGR ; SKKCIQVGGE ; FYTPNKFEDP ; SGNLKNKARS ; 300: GSSLKPVVRA ; KGAQVTIPGR ; DEQKVGQQCG ; VPPLPSLPSE ; PQVNQKNEDE ; 350: CAVCHDGGEL ; ICCDGCPRAF ; HLACLSPPLQ ; EIPSGLWRCS ; CCLQGRVQQN ; 400: LSQPEVSRPP ; ELPAETPILV ; GLRSASEKTR ; GPSRELKASS ; DAAVTYVNLL ; 450: APHPAAPLLE ; PSALCPLLSA ; GNEGRPGPAP ; SARCSVCGDG ; TEVLRCAHCA ; 500: AAFHWRCHFP ; TAAARPGTNL ; RCKSCSADST ; PTPGTPGEAV ; PTSGPRPAPG ; 550: LAKVGDDSAS ; HDPVLHRDDL ; ESLLNEHSFD ; GILQWAIQSM ; SRPLAETPPF ; 552: SS
Sequence Length	552
String	Q9Z0E3
Sub Unit	Homodimer and homotetramer. Interacts with CREBBP. Interacts preferentially with histone H3 that is not methylated at 'Lys-4'. Binds with lower affinity to histone H3 that is monomethylated at 'Lys-4'. Trimethylation of histone H3 at 'Lys-4' or phosphorylation at 'Thr-3' abolish the interaction. Binds with lower affinity to histone H3 that is acetylated at 'Lys-4', or that is acetylated at 'Lys-9' or trimethylated at 'Lys-9'. Binds histone H3 that is dimethylated at 'Arg-2' with very low affinity.

Uniprot	Q9Z0E3
Gene Name	Aire
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:11634
Unigene	Mm.35300

Reference	1. "Chromosomal localization and complete genomic sequence of the murine autoimmune regulator gene (Aire)." Shi J.-D., Wang C.-Y., Marron M.P., Ruan Q.-G., Huang Y.Q., Detter J.C., She J.-X. Autoimmunity31:47-53(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1A) 2. "Isolation and characterization of the mouse Aire gene." Mittaz L., Rossier C., Heino M., Petersen P., Krohn K.J.E., Gos A., Morris M.A., Kudoh J., Shimizu N., Antonarakis S.E., Scott H.S. Biochem. Biophys. Res. Commun.255:483-490(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1A) strain: 129/Sv. 3. "Cloning of Aire, the mouse homologue of the autoimmune regulator (AIRE) gene responsible for autoimmune polyglandular syndrome type 1 (ASP1)." Wang C.-Y., Shi J.-D., Davoodi-Semiromi A., She J.-X. Genomics55:322-326(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A) strain: C57BL/6. tissue: Thymus. 4. "The mouse Aire gene: comparative genomic sequencing, gene organization, and expression." Blechschmidt K., Schweiger M., Wertz K., Poulson R., Christensen H.-M., Rosenthal A., Lehrach H., Yaspo M.-L. Genome Res.9:158-166(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING strain: 129. 5. "Expression and alternative splicing of the mouse autoimmune regulator gene (Aire)." Ruan Q.-G., Wang C.-Y., Shi J.-D., She J.-X. J. Autoimmun.13:307-313(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B; 1C; 1D; 2A; 2B; 2C; 2D; 3A; 3B; 3C AND 3D) strain: C57BL/6. strain: NOD. strain: SJL. 6. "Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)." Halonen M., Pelto-Huikko M., Eskelin P., Peltonen L., Ulmanen I., Kolmer M. J. Histochem. Cytochem.49:197-208(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A);SUBCELLULAR LOCATION tissue: Kidney. tissue: Thymus. 7. "The autoimmune regulator (AIRE) is a DNA-binding protein." Kumar P.G., Laloraya M., Wang C.-Y., Ruan Q.-G., Davoodi-Semiromi A., Kao K.-J., She J.-X. J. Biol. Chem.276:41357-41364(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT STRUCTURE;PHOSPHORYLATION 8. "Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity." Koh A.S., Kuo A.J., Park S.Y., Cheung P., Abramson J., Bua D., Carney D., Shoelson S.E., Gozani O., Kingston R.E., Benoist C., Mathis D. Proc. Natl. Acad. Sci. U.S.A.105:15878-15883(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH THE N-TERMINUS OF UNMODIFIED HISTONE H3;INTERACTION WITH NUCLEOSOMES;DNA-BINDING;MUTAGENESIS OF ASP-299; VAL-303; CYS-312; CYS-313 AND PRO-328

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