Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Specificity
Natural and recombinant Mouse Arachidonate 5-lipoxygenase
Subcellular Location
Cytoplasm Nucleus matrix Nucleus membrane Peripheral membrane protein Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.