Succinic semialdehyde reductase ; SSA reductase ; Afar ; Akr7a5
Categories
Elisa
Function
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Specificity
Natural and recombinant Mouse Aflatoxin B1 aldehyde reductase member 2