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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse 5'-AMP-activated protein kinase subunit gamma-1

SKU : BHE13800365

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10187m
Alternative Names	Prkaac
Categories	Elisa
Function	AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Specificity	Natural and recombinant Mouse 5'-AMP-activated protein kinase subunit gamma-1
Entryname	AAKG1_MOUSE
Platform	PF00571
Protein Name	5'-AMP-activated protein kinase subunit gamma-1
Sequence	50: MESVAAESSP ; ALENEHFQET ; PESNNSVYTS ; FMKSHRCYDL ; IPTSSKLVVF ; 100: DTSLQVKKAF ; FALVTNGVRA ; APLWDSKKQS ; FVGMLTITDF ; INILHRYYKS ; 150: ALVQIYELEE ; HKIETWREVY ; LQDSFKPLVC ; ISPNASLFDA ; VSSLIRNKIH ; 200: RLPVIDPESG ; NTLYILTHKR ; ILKFLKLFIT ; EFPKPEFMSK ; SLQELQIGTY ; 250: ANIAMVRTTT ; PVYVALGIFV ; QHRVSALPVV ; DEKGRVVDIY ; SKFDVINLAA ; 300: EKTYNNLDVS ; VTKALQHRSH ; YFEGVLKCYL ; HETLETIINR ; LVEAEVHRLV ; 330: VVDEHDVVKG ; IVSLSDILQA ; LVLTGGEKKP ;
Sequence Length	330
String	O54950
Sub Unit	AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.

Uniprot	O54950
Gene Name	Prkag1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:19082
Unigene	Mm.6670

Reference	1. "Cloning, organisation, chromosomal localization and expression analysis of the mouse Prkag1 gene." Shamsadin R., Jantsan K., Adham I.M., Engel W. Cytogenet. Cell Genet.92:134-138(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Testis. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: C57BL/6. tissue: Eye. 3. "Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop." Loffler A.S., Alers S., Dieterle A.M., Keppeler H., Franz-Wachtel M., Kundu M., Campbell D.G., Wesselborg S., Alessi D.R., Stork B. Autophagy7:696-706(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ULK1 AND ULK2

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800365	E10187m	96T	$776		Add to Cart

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