Peptide O-xylosyltransferase 1 ; Xylosyltransferase I ; XT-I ; XT1
Categories
Elisa
Function
Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.
Specificity
Natural and recombinant Human Xylosyltransferase 1
Subcellular Location
Endoplasmic reticulum membrane Single-pass type II membrane protein Golgi apparatus membrane Single-pass type II membrane protein Secreted Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DISULFIDE BONDS;COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT;MUTAGENESIS OF CYS-257; CYS-276; CYS-285; CYS-301; CYS-471; CYS-542; CYS-561; CYS-563; CYS-572; CYS-574; CYS-675; CYS-920; CYS-927 AND CYS-933
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-959;TISSUE SPECIFICITY
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 159-171; 185-202; 289-296; 444-449; 593-598; 727-748 AND 948-959;GLYCOSYLATION
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;COFACTOR;MUTAGENESIS OF ASP-314; ASP-316; ASP-745; TRP-746 AND ASP-747
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;VARIANTS SER-115; TRP-406 AND MET-665